Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE Besides, compared to patients with p53-negative expression, those with p53-positive expression had a greater chance of developing metastasis, local recurrence and nerve infiltration as well as poorer 5-year overall survival (P < 0.01).In conclusion, the p53 expression is related to the survival of adenoid cystic carcinoma of salivary glands. 28206977 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Unlike common forms of TNBC, we found that AdCCs have a low mutation rate (0.27 non-silent mutations/Mb), lack mutations in TP53 and PIK3CA and display a heterogeneous constellation of known cancer genes affected by somatic mutations, including MYB, BRAF, FBXW7, SMARCA5, SF3B1 and FGFR2. 26095796 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease CTD_human The mutational landscape of adenoid cystic carcinoma. 23685749 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Although genome-wide imbalances have been characterized in conventional adenoid cystic carcinoma, other than p53 mutational status, the molecular profile of adenoid cystic carcinoma with high-grade transformation has not been explored. 21204718 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE We performed immunohistochemical assessment of p53 expression and TP53 mutational analysis of 15 malignant neoplasms arising from preexisting benign cylindroma, spiradenoma, and spiradenocylindroma, sporadic or associated with Brooke-Spiegler syndrome. 20075707 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 Biomarker disease BEFREE Conversely, p53 was positive in 53% of the mucoepidermoid carcinomas and in 20% of the adenoid cystic carcinomas. 15308260 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE Limited evidence suggests that p53 abnormalities in combination with HER-2/neu overexpression or loss of pRb expression may have a role in dedifferentiation of adenoid cystic carcinoma. 14681328 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE Surgically resected specimens of 13 carcinoid tumors of the lung including nine typical carcinoids and four atypical carcinoids, and eight salivary gland type carcinomas (six mucoepidermoid carcinomas and two adenoid cystic carcinomas) were analyzed regarding p53 expression, loss of heterozygosity (LOH) in chromosome 3p, 9p, and K-ras mutation. 12875635 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Molecular study confirmed the presence of p53 gene mutation selectively in the dedifferentiated component, suggesting a pivotal role of p53 gene alteration in the dedifferentiation process of adenoid cystic carcinoma. 11774177 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Seventeen adenoid cystic carcinomas (ACCs) and 27 mucoepidermoid carcinomas (MECs) occurring in the salivary glands were analyzed for p53 tumor suppressor gene alteration (exons 5-8) and protein expression. 11287288 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE DNA analysis at p53 locus in adenoid cystic carcinoma: comparison of molecular study and p53 immunostaining. 9648155 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 AlteredExpression disease BEFREE In contrast, one of the cases showed axillary lymph node metastases and in this case the primary tumor was large with a higher proliferative activity and expression of p53 protein, suggesting that these factors might play a role in the biological behavior of adenoid cystic carcinoma. 8685217 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE The role of p53 mutation and protein expression in primary and recurrent adenoid cystic carcinoma. 8666366 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.500 GeneticVariation disease BEFREE Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands. 8912832 1996
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
0.440 AlteredExpression disease BEFREE The Prognostic Significance of Notch1 and Fatty Acid Binding Protein 7 (FABP7) Expression in Resected Tracheobronchial Adenoid Cystic Carcinoma: A Multicenter Retrospective Study. 29141398 2018
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
0.440 Biomarker disease BEFREE Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma. 28914715 2017
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
0.440 Biomarker disease BEFREE NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem-Like Cells in Adenoid Cystic Carcinoma. 27084744 2016
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
0.440 GeneticVariation disease BEFREE Activating NOTCH1 point mutations were also identified in other solid tumors, including adenoid cystic carcinoma (ACC). 25104330 2014
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
0.440 Biomarker disease CTD_human The mutational landscape of adenoid cystic carcinoma. 23685749 2013
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
0.440 GeneticVariation disease CLINVAR
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.420 Biomarker disease BEFREE JQ1 and PI3K inhibition synergistically reduce salivary adenoid cystic carcinoma malignancy by targeting the c-Myc and EGFR signaling pathways. 30269363 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.420 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.420 GeneticVariation disease BEFREE Unlike common forms of TNBC, we found that AdCCs have a low mutation rate (0.27 non-silent mutations/Mb), lack mutations in TP53 and PIK3CA and display a heterogeneous constellation of known cancer genes affected by somatic mutations, including MYB, BRAF, FBXW7, SMARCA5, SF3B1 and FGFR2. 26095796 2015
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.420 Biomarker disease CTD_human The mutational landscape of adenoid cystic carcinoma. 23685749 2013