Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE We aimed to compare different techniques to detect active NE in sputum samples of 50 Bronchiectasis (BE) and 50 Cystic Fibrosis (CF) patients. 31626976 2019
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Neutrophils are major drivers of cystic fibrosis (CF) lung disease, in part due to the release of human neutrophil elastase- and myeloperoxidase-rich primary granules, leading to tissue damage. 29937317 2019
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE The lead NSGM so identified neutralized neutrophil elastase present in the sputum of CF patients in the presence of deoxyribonuclease and high-salt conditions. 31074986 2019
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Cystic fibrosis (CF) lung disease is characterized by aggressive neutrophil-dominated inflammation mediated in large part by neutrophil elastase (NE), an omnivorous protease released by activated or disintegrating neutrophils and a key therapeutic target. 29960875 2019
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Inhalation of POL6014 can safely lead to high concentrations within the lung and simultaneously low plasma concentrations, allowing for a clear inhibition of NE in the sputum of subjects with CF after single dosing. 31501052 2019
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Stability of SPLUNC1, S18 (the ENaC regulatory domain of SPLUNC1), and SPX-101 was determined in sputum from CF donors and towards neutrophil elastase. 29936069 2019
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Safety and efficacy of the human neutrophil elastase inhibitor BAY 85-8501 for the treatment of non-cystic fibrosis bronchiectasis: A randomized controlled trial. 30917927 2019
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Neutrophil elastase correlates with increased sphingolipid content in cystic fibrosis sputum. 29624923 2018
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 AlteredExpression disease BEFREE Lung disease in patients with CF is associated with neutrophil-dominated inflammation and elevated levels of the serine protease, neutrophil elastase (NE). 29401615 2018
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Our hypothesis is that variants of heparin, which potently inhibit NE but are not anticoagulant, would help restore the protease-antiprotease balance in CF. 29903912 2018
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Our results suggest that surface-bound NE activity may play an important role in the pathogenesis and serve as novel biomarker in CF lung disease. 29545279 2018
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE <i>Pseudomonas</i> on BAL was associated with positive neutrophil elastase (OR 4.17, 95% CI 2.04-8.53; p<0.001), increased interleukin-8 (p<0.001), increased all baseline PRAGMA computed tomography scores (p<0.001), progression of PRAGMA computed tomography scores (p<0.05) and increased risk of respiratory exacerbations (incidence rate ratio 2.11, 95% CI 1.15-3.87; p=0.017).In children with CF OPSs only marginally change the probability of detecting lower airway <i>Pseudomonas</i> and are not associated with lung disease indices nor exacerbations risk. 29678944 2018
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Plasma from 17 patients with CF (stable and pre and post pulmonary exacerbation) and eight healthy volunteers was analyzed for sTREM-1 and proteases (matrix metalloproteinase-8 (MMP-8), MMP-9, and human neutrophil elastase HNE). 28068000 2017
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE C5a levels also correlated positively with concentrations of other sputum markers associated with worse CF lung disease including neutrophil elastase (P < 0.001), myeloperoxidase activity (P = 0.006) and DNA concentration (P < 0.001). 28278205 2017
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE In contrast, MUC5B D-domains were modified by neutrophil elastase, a protease commonly found in CF sputum, demonstrating that proteolytic degradation of MUC5B is an extracellular event in CF sputum. 26993521 2016
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Both variants showed enhanced resistance to degradation in the presence of excess NE as well as CF patient sputum compared with SLPI-wild type (SLPI-WT). 26376365 2016
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Our results suggest that NE plays an important role in the in vivo pathogenesis and may serve as a therapeutic target for inflammation, mucus hypersecretion, and structural lung damage and indicate that additional rehydration strategies may be required for effective treatment of airway mucus obstruction in CF. 24678594 2014
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 AlteredExpression disease BEFREE In contrast to neutrophil elastase, CTSS activity was detectable in 100% of CF BAL fluid samples from patients without Pseudomonas aeruginosa infection. 24940638 2014
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Unlike control, CF human bronchial epithelial cultures (HBECs) where airway surface liquid (ASL) height was abnormally low (4.2 ± 0.6 μm), addition of S18 prevented ENaC-led ASL hyperabsorption and maintained CF ASL height at 7.9 ± 0.6 μm, even in the presence of neutrophil elastase, which is comparable to heights seen in normal HBECs. 24124190 2013
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE We hypothesized that the high load of NE in the CF airway triggers epithelial senescence by upregulating expression of p16, which inhibits cyclin-dependent kinase 4 (CDK4). 23316069 2013
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE We have shown that the active neutrophil elastase, protease 3, and cathepsin G in CF sputum resist inhibition in part by exogenous protease inhibitors. 22343221 2012
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Here, we show that the Pseudomonas proteases (Pseudomonas elastase and alkaline protease) and the neutrophil proteases (neutrophil elastase (NE) and proteinase-3) are capable of almost complete degradation of hemoglobin in vitro but that NE is the predominant protease that cleaves hemoglobin in vivo in CF bronchoalveolar lavage fluid. 21193404 2011
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis. 21343449 2011
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 Biomarker disease BEFREE Excess neutrophil elastase is an important determinant of pulmonary disease in CF. alpha1-antitrypsin (AAT), also known as alpha1-proteinase inhibitor (alpha1PI) is a major modulator of elastase activity. 11313771 2001
Entrez Id: 1991
Gene Symbol: ELANE
ELANE
0.100 AlteredExpression disease BEFREE There was also a clear association between CF ELF active NE and IL-8 levels (r = 0.94). 1357002 1992