Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 353
Gene Symbol: APRT
APRT
0.070 Biomarker disease BEFREE Deletion of Phe508 in the nucleotide binding domain (∆F508-NBD1) of the cystic fibrosis transmembrane regulator (CFTR; a cyclic AMP-regulated chloride channel) is the most frequent mutation associated with cystic fibrosis. 27241308 2016
Entrez Id: 353
Gene Symbol: APRT
APRT
0.070 AlteredExpression disease BEFREE This study tests the hypothesis that increased activity of AMP-activated protein kinase (AMPK), previously described in CF bronchial epithelial cells, causes these changes in fatty acid metabolism by driving desaturase expression. 24859760 2014
Entrez Id: 353
Gene Symbol: APRT
APRT
0.070 AlteredExpression disease BEFREE AMP-activated kinase (AMPK) is a ubiquitous metabolic sensor that inhibits the cystic fibrosis (CF) transmembrane conductance regulator (CFTR). 16361706 2006
Entrez Id: 353
Gene Symbol: APRT
APRT
0.070 Biomarker disease BEFREE Cystic fibrosis (CF) is caused by defective cyclic AMP-dependent cystic fibrosis transmembrane conductance regulator Cl(-) channels. 14701827 2004
Entrez Id: 353
Gene Symbol: APRT
APRT
0.070 Biomarker disease BEFREE To define whether PD non-CF and CF epithelial cells possess a functional cystic fibrosis transmembrane conductance regulator protein (CFTR) chloride channel, we analyzed the CFTR expression and the regulation of chloride secretion under cyclic (c)AMP stimulation in these regenerating PD epithelial cells of non-CF and CF airway tissue. 9287144 1997
Entrez Id: 353
Gene Symbol: APRT
APRT
0.070 Biomarker disease BEFREE Cystic fibrosis (CF) is a recessive genetic disease with thickened airway secretions that result from abnormal airway epithelial ion transport, including defective cyclic AMP-mediated Cl- (liquid) secretion and excessive Na+ (liquid) absorption. 7533608 1995
Entrez Id: 353
Gene Symbol: APRT
APRT
0.070 Biomarker disease BEFREE Cyclic-AMP-regulated chloride conductances are altered in airway epithelia from CF patients, suggesting that the functional expression of CFTR in the airways of CF patients may be a strategy for treatment. 7681548 1993