Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 GeneticVariation disease BEFREE Using CFBE41o cells, we showed that the positive SLC6A14 effect was mainly dependent on the nitric oxide (NO) synthase activity, nitrogen oxides, including NO, and phosphorylation by protein kinase G. These finding were confirmed in CF-HBE, as inducible NO synthase inhibition abrogated the functional interaction between SLC6A14 and pharmacological corrected F508del-CFTR. 31189070 2019
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 GeneticVariation disease BEFREE An initial cohort of 808 CF patients homozygous for the common CF mutation, DeltaF508, showed significant association for polymorphisms in the endothelin receptor A gene, EDNRA (P = 0.04), but not in the related endothelin genes (EDN1, EDN2, EDN3, or EDNRB) or NOS1, NOS2A, or NOS3. 20028935 2010
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 AlteredExpression disease BEFREE Inducible NOS mRNA expression was significantly lower in CF patients with and without bacterial infection than in healthy children (0.22 and 0.23 v 0.76; p=0.002 and p=0.01, respectively). 16517573 2006
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 AlteredExpression disease BEFREE Based on previous work demonstrating isoprenoid-mediated regulation of CF-related alterations in signal transducer and activator of transcription-1 (Stat1) and inducible nitric oxide synthase (NOS2) expression, the hypothesis of this study is that inhibition of isoprenoid-dependent signaling will restore SMAD3 expression and signaling in a model of CF epithelium. 15044214 2004
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 AlteredExpression disease LHGDN Here, CF cells secrete IFN-gamma-inducible factor(s), which stimulate NOS2 expression in NL cells, but not in CF cells. 15107292 2004
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 Biomarker disease BEFREE In contrast to a lack of NOS2 induction, the major histocompatibility complex class 2, an IFN-gamma-regulated delayed-responsive gene, is similarly induced in CF and non-CF airway epithelial (NL) cells, suggesting an NOS2-specific defect in the IFN-gamma signaling pathway. 15107292 2004
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 AlteredExpression disease BEFREE Inhibition of the Rho GTPase pathway at the level of isoprenoid/cholesterol synthesis with mevastatin reduces PIAS1 expression, increases STAT1 activation, and restores NOS2 expression in models of CF epithelium, suggesting that pharmacological inhibition of the isoprenoid synthesis/Rho GTPase pathway may represent a potential avenue for therapeutic intervention for CF. 12948935 2003
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 AlteredExpression disease LHGDN Inhibition of the Rho GTPase pathway at the level of isoprenoid/cholesterol synthesis with mevastatin reduces PIAS1 expression, increases STAT1 activation, and restores NOS2 expression in models of CF epithelium, suggesting that pharmacological inhibition of the isoprenoid synthesis/Rho GTPase pathway may represent a potential avenue for therapeutic intervention for CF. 12948935 2003
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 AlteredExpression disease BEFREE NO donor or NOS2 overexpression provides protection from virus infection in CF, suggesting that NO is sufficient for antiviral host defense in the human airway and is one strategy for antiviral therapy in CF children. 12753739 2003
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 AlteredExpression disease BEFREE These complexes effect partial correction of the chloride transport defect as assessed by in vivo nasal potential difference measurements, produce immunohistochemical staining for CFTR, and restore expression of nitric oxide synthase-2 (NOS-2), which is downregulated in the epithelium of mice and humans with cystic fibrosis. 11945068 2002
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 AlteredExpression disease BEFREE We propose that increased levels of PIAS1 diminish certain cell-signaling pathways, resulting in reduced IRF-1 and NOS2 expression in CF epithelial cells. 10930443 2000
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 AlteredExpression disease BEFREE Human neutrophils were activated by incubation with cytokines, added to monolayers of normal (16HBE14o-) and CF (CFBE41o-) bronchial epithelial cells and co-cultured for up to 72 h. Marked up-regulation of iNOS protein expression was seen in normal bronchial epithelial cells following neutrophil co-culture but the CF cells showed a significantly smaller increase (p<0.001). 10657009 2000
Entrez Id: 4843
Gene Symbol: NOS2
NOS2
0.100 AlteredExpression disease BEFREE To understand better the poor resistance to infections in the CF lung, the expression of the iNOS gene was investigated in explanted lungs from patients with cystic fibrosis (n = 13), bronchiectasis (n = 3), emphysema (n = 14), and in normal lungs (n = 8). 9614386 1998