| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.060 | Biomarker | disease | BEFREE | Actin filament dynamics were characterized, which regulate the CF phenotype in response to biomechanical signals. | 30575422 | 2019 | ||||
|
0.060 | AlteredExpression | disease | BEFREE | Rheology data indicated that both rhDNase and PEG40-rhDNase presented similar mucolytic activity in CF sputa, independently of the purulence of the sputum samples as well as of their DNA, actin and ions contents. | 29871879 | 2018 | ||||
|
0.060 | Biomarker | disease | BEFREE | Since both histones and F-actin are present in the sputum of patients with cystic fibrosis, therefore, the formation of the stable histone-actin bundles can contribute to the pathology of this disease by increasing the viscosity of the sputum. | 28846729 | 2017 | ||||
|
0.060 | GeneticVariation | disease | BEFREE | Both the small molecules trimethylangelicin (TMA) and VX-809, which act as 'correctors' for F508del CFTR by rescuing F508del-CFTR-dependent chloride secretion, also restore the apical expression of phosphorylated ezrin and actin organization and increase cAMP and activated PKA submembrane compartmentalization in both primary and secondary cystic fibrosis airway cells. | 26823603 | 2016 | ||||
|
0.060 | Biomarker | disease | BEFREE | In cystic fibrosis (CF), actin and DNA originating from inflammatory cells contribute to the thickness of airway secretions. | 11316652 | 2001 | ||||
|
0.060 | Biomarker | disease | BEFREE | We present a novel approach to study sputum structure using fluorescence microscopy to confirm the presence of large DNA-rich fibers and visualize for the first time filamentous actin in all sputum samples examined from patients with cystic fibrosis and chronic bronchitis. | 8774146 | 1996 |