Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | disease | BEFREE | Taken together, our study shows that curcumin down-regulates TLR2 gene expression and function in CF bronchial epithelial cells possibly by accelerating SP1 degradation via an oxidative process. | 30626802 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | Our findings indicate that variations in TLR1, TLR2 and TLR5 genes may influence CF lung function decline. | 23994582 | 2013 | ||||
|
0.070 | Biomarker | disease | BEFREE | To our knowledge, this study is the first to report of a role for TOM1 in the TLR2/4 signaling pathways and the first to describe microRNA involvement in CF. | 20083669 | 2010 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Inhibition of SP1 with mithramycin A decreased TLR2 expression in both CF and 5-azacytidine-treated non-CF epithelial cells. | 18423053 | 2008 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Taken together, our results demonstrate that TLR2 expression is epigenetically up-regulated in CF bronchial epithelial cells and suggest that TLR2 overexpression or prolonged activation of TLR2 signaling might be critical in CF pathogenesis. | 16478769 | 2006 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | To investigate TLR4 and TLR2 expression in the bronchial mucosa of patients with CF and normal control subjects. | 15776129 | 2005 | ||||
|
0.070 | Biomarker | disease | BEFREE | Increased availability of TLR2 at the apical surfaces of CF epithelial cells is consistent with the increased proinflammatory responses seen in CF airways and suggests a selective participation of TLRs in the airway mucosa. | 14656745 | 2004 |