The TIUKO CF rat developed lung fibrosis, chronic inflammation, reactive airway disease, and the CF Antigen (MRP8/14), a marker for CF in human patients, was expressed.
We have demonstrated for the first time, by Northern analysis, the presence of the S-100 calcium binding proteins MRP8 (also called "cystic fibrosis protein") and MRP14 mRNAs in cultured human tracheal gland cells, obtained from normal and cystic fibrosis (CF) patients.