Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5972
Gene Symbol: REN
REN
0.060 AlteredExpression phenotype BEFREE During periods of dehydration and salt deprivation renal Mesenchymal Stromal Cells (MSCs) differentiate to JG cells undergo expansion, and smooth muscle cells along the afferent arteriole re-differentiate to express renin. 31760770 2020
Entrez Id: 100505887
Gene Symbol: LINC01672
LINC01672
0.040 Biomarker phenotype BEFREE The dominance of dehydration effects in relation to TSC is observed from the positive enthalpy changes in calorimetry studies and the negative chemical shifts in 1H NMR studies. 31808761 2020
Entrez Id: 10473
Gene Symbol: HMGN4
HMGN4
0.010 Biomarker phenotype BEFREE NHC-catalyzed silylative dehydration of primary amides to nitriles at room temperature. 31830152 2020
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.010 Biomarker phenotype BEFREE Following these clues provides a unifying common basis to non-canonical 3-MGAs: constitutive mitochondrial dysfunction induces AMPK activation which, by inhibiting early steps in cholesterol and fatty acid syntheses, pipelines cytoplasmic acetyl-CoA to peroxisomes where a rise in HMG-CoA followed by local dehydration and hydrolysis may lead to 3-MGA yield. 31626852 2020
Entrez Id: 5563
Gene Symbol: PRKAA2
PRKAA2
0.010 Biomarker phenotype BEFREE Following these clues provides a unifying common basis to non-canonical 3-MGAs: constitutive mitochondrial dysfunction induces AMPK activation which, by inhibiting early steps in cholesterol and fatty acid syntheses, pipelines cytoplasmic acetyl-CoA to peroxisomes where a rise in HMG-CoA followed by local dehydration and hydrolysis may lead to 3-MGA yield. 31626852 2020
Entrez Id: 2194
Gene Symbol: FASN
FASN
0.010 Biomarker phenotype BEFREE Mechanisms of Resistance Associated with the Inhibition of the Dehydration Step of Type II Fatty Acid Synthase in <i>Mycobacterium tuberculosis</i>. 31775512 2020
Entrez Id: 5564
Gene Symbol: PRKAB1
PRKAB1
0.010 Biomarker phenotype BEFREE Following these clues provides a unifying common basis to non-canonical 3-MGAs: constitutive mitochondrial dysfunction induces AMPK activation which, by inhibiting early steps in cholesterol and fatty acid syntheses, pipelines cytoplasmic acetyl-CoA to peroxisomes where a rise in HMG-CoA followed by local dehydration and hydrolysis may lead to 3-MGA yield. 31626852 2020
Entrez Id: 551
Gene Symbol: AVP
AVP
0.600 AlteredExpression phenotype BEFREE Identification of neuropeptides in the HNS and analysis of neuropeptide profiles in extracts from individual camels using mass spectrometry indicates that overall AVP peptide levels decreased in the HNS during summer compared to winter, perhaps due to increased release during periods of dehydration in the dry season. 31211771 2019
Entrez Id: 551
Gene Symbol: AVP
AVP
0.600 Biomarker phenotype BEFREE In the current review, we summarize the literature on the relationship between elevated osmolarity, AVP, copeptin, and dehydration with renal and cardiovascular outcomes and underlying classical and novel pathophysiologic pathways. 31365096 2019
Entrez Id: 6338
Gene Symbol: SCNN1B
SCNN1B
0.140 Biomarker phenotype BEFREE The epithelial sodium channel ENaC consists of three subunits encoded by Scnn1a, Scnn1b, and Scnn1g and increased sodium absorption through this channel is hypothesized to lead to mucus dehydration and accumulation in cystic fibrosis (CF) patients. 30100257 2019
Entrez Id: 6340
Gene Symbol: SCNN1G
SCNN1G
0.120 Biomarker phenotype BEFREE The epithelial sodium channel ENaC consists of three subunits encoded by Scnn1a, Scnn1b, and Scnn1g and increased sodium absorption through this channel is hypothesized to lead to mucus dehydration and accumulation in cystic fibrosis (CF) patients. 30100257 2019
Entrez Id: 359
Gene Symbol: AQP2
AQP2
0.100 AlteredExpression phenotype BEFREE Accordingly, female mice concentrate urine better than males upon dehydration due to increased AQP2 expression and mobilization. 31386675 2019
Entrez Id: 359
Gene Symbol: AQP2
AQP2
0.100 AlteredExpression phenotype BEFREE Mice treated with both PPG and AOAA developed a urine concentration defect in response to dehydration that was accompanied by reduced AQP-2 protein expression. 30036087 2019
Entrez Id: 359
Gene Symbol: AQP2
AQP2
0.100 Biomarker phenotype BEFREE Arginine Vasopressin-Aquaporin-2 Pathway-Mediated Dehydration Effects of Electroacupuncture in Guinea Pig Model of AVP-Induced Eendolymphatic Hydrops. 29335859 2019
Entrez Id: 1080
Gene Symbol: CFTR
CFTR
0.100 GeneticVariation phenotype BEFREE Cystic fibrosis (CF) is a disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) that in the airways result in reduced Cl<sup>-</sup> secretion and increased Na<sup>+</sup> absorption, airway surface liquid (ASL) dehydration, decreased mucociliary clearance, infection and inflammation leading to lung injury. 31344409 2019
Entrez Id: 359
Gene Symbol: AQP2
AQP2
0.100 Biomarker phenotype BEFREE This process involves the targeting of AQP2 to the apical membrane during dehydration as well as its removal when hydration levels have been restored. 31661793 2019
Entrez Id: 5972
Gene Symbol: REN
REN
0.060 GeneticVariation phenotype BEFREE Age-associated neurohormonal changes particularly affecting the renin angiotensin aldosterone system (RAAS), alterations in thermoregulatory mechanisms, changes in renal function and body composition render older persons vulnerable to dehydration, renal failure, heat stroke and increased mortality. 31268494 2019
Entrez Id: 5972
Gene Symbol: REN
REN
0.060 Biomarker phenotype BEFREE Renin-angiotensin system (RAS) inhibitors carry a risk of normotensive ischemic acute kidney injury in dehydration and concurrent nonsteroidal anti-inflammatory drug (NSAID) use. 31038268 2019
Entrez Id: 6524
Gene Symbol: SLC5A2
SLC5A2
0.050 Biomarker phenotype BEFREE Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats. 30710078 2019
Entrez Id: 100505887
Gene Symbol: LINC01672
LINC01672
0.040 Biomarker phenotype BEFREE NMR and light-scattering data indicated that the nanogel core shrinks upon dehydration below T<sub>p</sub> and swells upon hydration above T<sub>p</sub>. 31035754 2019
Entrez Id: 100505887
Gene Symbol: LINC01672
LINC01672
0.040 Biomarker phenotype BEFREE Here we report the observation of a triethyloxonium ion (TEO) in the dehydration of ethanol on zeolite H-ZSM-5 by using ex situ and in situ solid-state NMR spectroscopy. 31036815 2019
Entrez Id: 3783
Gene Symbol: KCNN4
KCNN4
0.030 GeneticVariation phenotype BEFREE All HX-associated KCNN4 mutants studied to date have revealed increased current magnitude and red cell dehydration. 31091145 2019
Entrez Id: 3783
Gene Symbol: KCNN4
KCNN4
0.030 Biomarker phenotype BEFREE Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease. 31352162 2019
Entrez Id: 84680
Gene Symbol: ACCS
ACCS
0.020 Biomarker phenotype BEFREE The effect of bougie size and distance from the pylorus on dehydration after laparoscopic sleeve gastrectomy: an analysis of the ACS-MBSAQIP database. 31582292 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.020 Biomarker phenotype BEFREE Either additional co-medication with hydrochlorothiazide or dehydration rather than co-medication with ACE inhibitors could be identified as necessary factors for lithium intoxication. 30805791 2019