Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.100 Biomarker disease BEFREE Alpha-synuclein is a major component of Lewy bodies (LBs) in Parkinson disease and dementia with LBs and of glial cytoplasmic inclusions in multiple system atrophy. 11708989 2001
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.100 Biomarker disease BEFREE Granulocyte-macrophage colony-stimulating factor (GM-CSF) is elevated in cerebrospinal fluid in HIV- associated dementia; in addition, therapeutic GM-CSF elevates plasma viral load. 11834953 2002
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
0.370 GeneticVariation disease BEFREE MTHFR genotype was not found to influence homocysteine levels, although the T allele was found to increase risk for VaD and perhaps dementia after stroke. 12364720 2002
Entrez Id: 410
Gene Symbol: ARSA
ARSA
0.030 AlteredExpression disease BEFREE Arylsulfatase A activity was slightly but not significantly decreased in leukocytes derived from subjects with dementia and Down syndrome in comparison with age-matched control samples. 12459318 2003
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Apolipoprotein E, angiotensin-converting enzyme and alpha-1-antichymotrypsin genotypes are not associated with post-stroke dementia. 12736093 2003
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
0.400 Biomarker disease BEFREE FTDP-17 begins with executive function deficits and other abnormal behaviors, which progress to dementia. 12872001 2003
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Apolipoprotein E polymorphism and low density lipoprotein (LDL) oxidation in patients with dementia. 12899198 2003
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Apolipoprotein E in Taiwan Chinese patients with dementia. 14512715 2003
Entrez Id: 51324
Gene Symbol: SPG21
SPG21
0.010 GeneticVariation disease BEFREE Maspardin is mutated in mast syndrome, a complicated form of hereditary spastic paraplegia associated with dementia. 14564668 2003
Entrez Id: 5444
Gene Symbol: PON1
PON1
0.050 GeneticVariation disease BEFREE Paraoxonase 1 gene polymorphisms and dementia in humans. 15016430 2004
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence. 15079025 2004
Entrez Id: 351
Gene Symbol: APP
APP
0.400 GeneticVariation disease BEFREE APP is an important locus predicting the age at onset of dementia in people with Down syndrome. 15184603 2004
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.020 AlteredExpression disease BEFREE Lipoprotein(a) [Lp(a)] level is a newly established vascular risk factor which has been suggested to play a role in dementia. 15211075 2004
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.060 AlteredExpression disease BEFREE MCP-1 levels are increased in CSF of patients with Alzheimer's disease (AD) compared with controls, suggesting a role in the development of dementia. 15312962 2004
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Apolipoprotein E as vascular risk factor in neurodegenerative dementia. 15375590 2004
Entrez Id: 7305
Gene Symbol: TYROBP
TYROBP
0.090 Biomarker disease BEFREE Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy should be considered in adult patients under age 50 years with dementia and basal ganglia calcification. 15883308 2005
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Apolipoprotein E (APOE) epsilon4 gene dose (i.e., the number of epsilon4 alleles in a person's APOE genotype) is associated with a higher risk of AD and a younger age at dementia onset. 15932949 2005
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE APOE genotype, age of onset, disease duration, smoking history, and dementia status were collected for families with PD, yielding 324 Caucasian families with complete information. 16116614 2006
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.030 Biomarker disease BEFREE ALDH2*2 does not seem to be important in the etiology of dementia. 16250071 2005
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia. 16389198 2006
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE APOE epsilon4 constitutes a risk factor for dementia, mild injury in isolation does not increase the risk, but head injury in combination with the APOE epsilon4 leads to increased risk of dementia. 16684399 2007
Entrez Id: 25978
Gene Symbol: CHMP2B
CHMP2B
0.070 GeneticVariation disease BEFREE CHMP2B mutations are not a cause of dementia in Dutch patients with familial and sporadic frontotemporal dementia. 16941655 2006
Entrez Id: 12
Gene Symbol: SERPINA3
SERPINA3
0.060 AlteredExpression disease BEFREE ACT has been shown to promote Abeta polymerization in vitro and in vivo, and levels of ACT protein in plasma and cerebrospinal fluid from Alzheimer's patients have been found to correlate with progression of dementia. 16987932 2006
Entrez Id: 71
Gene Symbol: ACTG1
ACTG1
0.010 AlteredExpression disease BEFREE ACT has been shown to promote Abeta polymerization in vitro and in vivo, and levels of ACT protein in plasma and cerebrospinal fluid from Alzheimer's patients have been found to correlate with progression of dementia. 16987932 2006
Entrez Id: 345651
Gene Symbol: ACTBL2
ACTBL2
0.010 AlteredExpression disease BEFREE ACT has been shown to promote Abeta polymerization in vitro and in vivo, and levels of ACT protein in plasma and cerebrospinal fluid from Alzheimer's patients have been found to correlate with progression of dementia. 16987932 2006