Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.390 GeneticVariation disease BEFREE No difference was found by a cross-sectional approach comparing IL-1α rs1800587, IL-1β rs3087258 and TNF-α rs1799724 genotypic and allelic frequencies between those affected and not affected by dementia. 21509504 2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.390 GeneticVariation disease BEFREE A recent study has shown that a promoter polymorphism of the IL-1β gene (rs16944) is associated with cognitive performance in elderly males without dementia. 21614008 2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.390 GeneticVariation disease BEFREE This study tests the hypothesis that a biallelic functional polymorphism in the promoter region (position-511) (rs16944) of the IL-1 beta gene is associated with cognitive performance in elderly males without dementia. 19013689 2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.390 Biomarker disease CTD_human Association between the interleukin-1beta polymorphisms and Alzheimer's disease: a systematic review and meta-analysis. 18675847 2008
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.390 Biomarker disease BEFREE Inflammatory events may contribute to the pathogenesis of dementia and interleukin-1 (IL-1) may exert both neurotoxic and neuroprotective effects. 17622713 2007
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.390 GeneticVariation disease BEFREE Our results support the hypothesis that certain genetic variations contained within the IL-1 gene family contribute to the pathogenesis of dementia. 16226351 2006
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.390 GeneticVariation disease BEFREE These data do not support the hypothesis that the IL-1-beta-511 and IL-6-174 polymorphisms affect dementia or AD risk. 16297587 2006
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.390 Biomarker disease BEFREE This review will focus on the intracerebral production of the pro- and anti-inflammatory cytokines interleukin IL-1beta, IL-1 receptor antagonist (IL-1ra), IL-6 and TNF-alpha in dementia, and their relation to gene polymorphism, to cerebral neuronal damage, apoptosis, and to clinical variables of dementia. 12909295 2003
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.390 Biomarker disease BEFREE Thus, IL-1 beta appears to play a major role in the regulation of chemokines during cellular interactions in HIV-associated dementia, but other factors may also be involved. 11031691 2000
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.390 AlteredExpression disease BEFREE Increased levels of tumor necrosis factor-alpha messenger RNA were not associated with increased levels of IL-1 beta messenger RNA, suggesting differential regulation of these monokines in acquired immunodeficiency syndrome dementia.(ABSTRACT TRUNCATED AT 250 WORDS) 8498837 1993