|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
IgG ELISA using a mixture of DENV1-4 NS1 proteins detected different primary and secondary DENV infections with a sensitivity of 95.6% and specificity of 89.5%.
|
30429254 |
2019 |
|
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we developed a high-throughput and multiplex IgG microsphere immunoassay (MIA) using the NS1 proteins of DENV1-DENV4, ZIKV and West Nile virus (WNV) to test samples from reverse-transcription-polymerase-chain reaction-confirmed cases, including primary DENV1, DENV2, DENV3, WNV and ZIKV infections, secondary DENV infection, and ZIKV infection with previous DENV infection.
|
31442225 |
2019 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dynamic behavior of Dengue and Zika viruses NS1 protein reveals monomer-monomer interaction mechanisms and insights to rational drug design.
|
31594455 |
2019 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dengue virus (DENV) nonstructural 1 (NS1) protein is a specific and sensitive biomarker for the diagnosis of dengue.
|
31553730 |
2019 |
|
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These usually refer to host immune responses, including antibody-dependent enhancement, cytokine expression, and dengue virus particles including NS1 protein, which lead to cell death by both apoptosis and pyroptosis.
|
27860556 |
2018 |
|
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, during both acute secondary DENV1 and DENV2 infection, the antibody repertoire of DF and DHF patients is directed towards distinct regions of the NS1 protein.
|
30531923 |
2018 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dasatinib, a Src-family kinase (SFK) inhibitor that inhibits Src phosphorylation, prevents enhanced permeability induced by direct DENV infection whereas in NS1 protein-treated cells its effect is less significant.
|
30355397 |
2018 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
A prototype for the differential detection of dengue and/or Zika NS1 protein was developed.
|
28295400 |
2017 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to demonstrate the utility of dengue virus (DENV) non structural protein 1 (NS1) based rapid diagnostic test (RDT) for use in tribal and difficult to reach areas for early dengue (DEN) diagnosis in acute phase patients and evaluate its sensitivity and specificity against DENV NS1 enzyme linked immune sorbent assay (ELISA) and real time reverse transcriptase polymerase chain reaction (qRT-PCR).
|
28042883 |
2017 |
|
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Phylogenetic analysis based on partial E-NS1 gene sequences showed that the DENV-3 viruses belonged to genotype III with maximum homology with the dengue-3 strains previously reported from Pakistan and India.
|
28219668 |
2017 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The secreted NS1 protein of dengue virus activates macrophages and human PBMCs via TLR4 and induce the release of pro-inflammatory cytokines which is responsible for the pathogenesis of disease.
|
27302095 |
2016 |
|
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of dengue-2 virus NS1 protein in Nicotiana tabacum plants for development of dengue immunodiagnostic kits.
|
25689887 |
2015 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
To our knowledge, this is the first report on the successful production of functionally active recombinant dengue-2 NS1 protein production without undergoing any in vitro posttranslational modification process.
|
24089673 |
2013 |
|
IVNS1ABP
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Optimization of Dengue-3 recombinant NS1 protein expression in E. coli and in vitro refolding for diagnostic applications.
|
23188193 |
2013 |
|
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study described the performance of Panbio Dengue Early NS1 and IgM Capture ELISA assays for dengue detection during our surveillance in eight cities in Indonesia as well as the genetic diversity of DENV NS1 genes and its relationship with the NS1 detection.
|
24571329 |
2013 |
|
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present work, we evaluated the immune responses, protection to type 2 dengue virus (DENV2) challenges and safety parameters in BALB/c mice vaccinated with a recombinant NS1 protein in combination with three different adjuvants: aluminum hydroxide (alum), Freund's adjuvant (FA) or a genetically detoxified derivative of the heat-labile toxin (LT(G33D)), originally produced by some enterotoxigenic Escherichia coli (ETEC) strains.
|
22178517 |
2012 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
Super induction of dengue virus NS1 protein in E. coli.
|
19232392 |
2009 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The E/NS1 gene of dengue 2 virus variants derived from serial passages in Vero or C6/36 cells, or alternately in both cell systems, was amplified and sequenced in order to observe gene modification after serial passages.
|
14555849 |
2003 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
To study the B-cell epitopes of nonstructural 1 (NS1) glycoprotein and anti-NS1 antibody response in DEN infection, a series of 15-mer synthetic peptides from the predicted B-cell linear epitopes of DEN-2 NS1 protein were prepared.
|
9890415 |
1999 |
|
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using a universal primer set designed to match the sequence of the NS1 gene of flaviviruses, the virus RNA of dengue (DEN), Japanese encephalitis (JEV), powassan and langat of Flaviviridae were successfully amplified by polymerase chain reaction (PCR) via cDNA; and with different internal primers, the serotypes of the dengue viruses were identified.
|
9130232 |
1997 |
|
IVNS1ABP
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we have analyzed four dengue-2 Cuban strains for two short genomic fragments: one on the envelope (E) glycoprotein and one at the E/nonstructural protein-1 (NS1) gene junction.
|
7694966 |
1995 |
|
IVNS1ABP
|
0.100 |
Biomarker
|
disease |
BEFREE |
The sequences were combined with those published and classified elsewhere to provide a comprehensive E/NS 1 gene taxonomy of dengue-2 virus isolates.
|
1829885 |
1991 |