Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 GeneticVariation disease BEFREE The sequences of infections which produced a higher risk of dengue fever upon secondary infection are: DEN1 followed by DEN2; DEN1 followed by DEN4; DEN2 followed by DEN3; and DEN4 followed by DEN3. 31253823 2019
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE Dengue is one of the most important and widespread viral infection comprises 4 related serotypes (DEN-1, 2, 3, and 4). 29247706 2018
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE Several other vaccine approaches have been developed including live attenuated chimeric dengue vaccines (DENVax and LAV Delta 30), DEN protein subunit V180 vaccine (DEN1-80E) and DENV DNA vaccines. 28281864 2017
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 GeneticVariation disease BEFREE There are five dengue viruses, called serotypes (DEN-1, DEN-2, DEN-3, DEN-4, and DEN-5), which belong to the Flaviviridae family and are transmitted to humans through infected mosquito bites, with the main vector the Aedes aegypti mosquito (Linnaeus, 1762).Studies performed with Ae. aegypti, aimed at their identification and analysis of their population structure, are fundamental to improve understanding of the epidemiology of dengue, as well for the definition of strategic actions that reduce the transmission of this disease. 28560571 2017
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE The DENV assay results, in agreement with the serological tests and sequencing analysis, showed that the pathogen resulting in the DF explosion in Guangdong in 2006 belonged to DEN-1. 19018028 2008
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE The competitor provides a suitable internal control useful to quantify viral RNA from all four dengue virus (DEN 1-4) serotypes. 18597860 2008
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE The results show that 45 people were positive for dengue-specific IgM (27 males and 18 females), while RT-PCR detected dengue viral RNA in 12 patients, 3 identified as DEN-1 and 9 as DEN-2. 17642533 2007
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE Predominance of DEN-1 in 1998 and DEN-3 re-introduction and predominance in 2001-2003 coincided with outbreaks. 17160279 2006
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE To find fast and reliable methods to diagnose dengue in the early phase of the disease, patient acute-phase sera were investigated for the presence of dengue-specific immunoglobulin M (IgM) antibodies by enzyme-linked immunosorbent assay (ELISA) and also for dengue serotype (DEN-1 to DEN-4)-specific RNA by different PCR assays. 15956408 2005
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE In 2001, an autochthonous case of dual viremia, resulting from naturally acquired dengue virus DEN-1 and DEN-2 infections was detected during the dengue outbreak that occurred in Barretos, a city with about 105,000 inhabitants in the North region of São Paulo State. 12751316 2003
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE Conversely, HLA-B*51 was associated with the development of DHF in patients with secondary infections, and HLA-B*52 was associated with DF in patients with secondary DEN-1 and DEN-2 infections. 12472660 2002
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE When sera were tested for plaque-reduction neutralizing antibodies to DEN 1-4 viruses, nearly 85% had antibodies to two or more DEN serotypes. 11561700 2001
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE Using a serotype-specific monoclonal antibody (MAb) of dengue virus type 1 (DEN-1), 15F3-1, we identified the B-cell epitope of DEN-1 from a random peptide library displayed on phage. 11230414 2001
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE During the observation period, primary dengue infection rates were DEN 1 = 4.8%, DEN 2 = 7.7%, DEN 3 = 4.2%, and DEN 4 = 3.4%, while two or more dengue infections occurred in 6.7% of the study population. 10497982 1999
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE A split decomposition analysis of dengue (DEN) virus gene sequences revealed extensive networked evolution, indicative of recombination, among DEN-1 strains but not within serotypes DEN-2, DEN-3, or DEN-4. 10331266 1999
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE Maximum nucleotide sequence variation was 6.9% and 4.9% for DEN-1 and DEN-4 viruses, respectively. 9049396 1995
Entrez Id: 123228
Gene Symbol: SENP8
SENP8
0.100 Biomarker disease BEFREE Four recombinant vaccinia viruses expressing different portions of the dengue type 1 virus (DEN-1) genome (C-prM-E-NS1-NS2A-NS2B; prM-E; prM-E-NS1-NS2A-NS2B; or NS1-NS2A) were constructed in order to establish the most immunogenic configuration of DEN-1 proteins. 8165861 1994