|
LINC02210-CRHR1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
EA treatment can decrease the expression of hypothalamic CRF and CRF-R1, relieve anxiety and depression, meanwhile reduce the expression of CRF-R1 in the gastrointestinal mucosa, increase ZO-1 expression, and adjust tight junctions (TJs) to repair the intestinal mucosal barrier.
|
31737064 |
2019 |
|
LINC02210-CRHR1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression.
|
30499109 |
2019 |
|
LINC02210-CRHR1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we demonstrated that chronic FS stress (CFSS) could activate corticotropin-releasing factor (CRF)/CRF receptor type 1 (CRFR1) signaling in the BLA, and blockade of CRF/CRFR1 signaling by intra-BLA injection of NBI27914 (NBI), a selective CRFR1 antagonist, could prevent the CFSS-induced depressive-like behaviors in rats, indicating that activation of CRF/CRFR1 signaling in the BLA is required for CFSS-induced depression.
|
29080675 |
2018 |
|
LINC02210-CRHR1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor receptor type 1 (CRF1R) is a class B receptor mediating stress response and also considered a drug target for depression and anxiety.
|
28183242 |
2017 |
|
LINC02210-CRHR1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS to predict depression, cognitive functions and hippocampal activity.
|
28461011 |
2017 |
|
LINC02210-CRHR1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Allelic variants of the glucocorticoid receptor (GR) gene contribute significantly to both cortisol levels and to measures of psychosis; corticotropin-releasing hormone receptor 1 variants contribute to measures of depression and psychosis.
|
24933348 |
2015 |
|
LINC02210-CRHR1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variants in the corticotropin-releasing hormone receptor 1 (CRHR1) gene have been associated with alcoholism and depression.
|
25802844 |
2015 |
|
LINC02210-CRHR1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity.
|
24931706 |
2014 |
|
LINC02210-CRHR1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, GR and corticotropin-releasing hormone receptor 1 (CRHR1) genotypes contributed significantly to psychosis measures and CRHR1 contributed significantly to depression severity rating.
|
24166410 |
2014 |
|
LINC02210-CRHR1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Accumulating research suggests a moderating role for the corticotropin-releasing hormone receptor 1 gene (CRHR1) in the association between childhood adversity and adult depression.
|
22748421 |
2013 |
|
LINC02210-CRHR1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several studies have demonstrated that variants of the CRH-R1 gene carry a potential risk for depression, but evidence for an association between CRH-R1 genotypes and IBS is lacking.
|
22957021 |
2012 |
|
LINC02210-CRHR1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stress and anxiety disorders are risk factors for depression and these behaviors are modulated by corticotrophin-releasing factor receptor 1 (CRFR1) and serotonin receptor (5-HT(2)R).
|
20383137 |
2010 |
|
LINC02210-CRHR1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly, we recently discovered that genetic variation in components of the stress-related hypothalamic pituitary adrenocortical axis, T-box 19 and corticotropin releasing hormone receptor 1, showed association and linkage to high anger/hostility in and male depression the suicidal offspring, respectively.
|
17585962 |
2007 |
|
LINC02210-CRHR1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accumulating evidence supports a role for nonpeptide CRF1 receptor antagonists among the future pharmacotherapies for the treatment of depression.
|
16122764 |
2006 |
|
LINC02210-CRHR1
|
0.100 |
Biomarker
|
disease |
BEFREE |
CRH receptor 1 (CRHR1), which we first mapped in the brain in 1994, has been implicated in the treatment of depression and anxiety.
|
15365580 |
2004 |