|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study investigated the association of 5-HTTLPR polymorphism and CpG DNA methylation (5mC) levels of an AluJb repeat element at the SLC6A4 promoter region in mother-child pairs exposed to maternal depression.
|
30447571 |
2019 |
|
LOC110806262
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Hypermethylation of the serotonin transporter gene promoter in panic disorder-Epigenetic imprint of comorbid depression?
|
31353282 |
2019 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the effect of 5-HTT promoter variation on the relationship between the loss of parent or partner and depression was examined.
|
22884012 |
2013 |
|
LOC110806262
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Higher SLC6A4 promoter methylation status was significantly associated with childhood adversities, worse clinical presentation (family history of depression, higher perceived stress, and more severe psychopathology assessed by SOFAS, WHODAS-12, and WHOQOL-BREF), but was not associated with treatment outcomes after considering multiple comparisons.
|
23333376 |
2013 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The serotonin transporter gene promoter polymorphism (5HTTLPR) and child abuse have been associated with an increased risk for depression.
|
22311265 |
2012 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The serotonin transporter gene (SLC6A4) promoter polymorphism (5HTTLPR) has been associated with individual stress responses such that individuals with childhood abuse history have higher rates of depression in later life if they are homozygous short (s/s) of the gene.
|
22236459 |
2012 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variation in the serotonin transporter gene (SLC6A4) promoter region has been shown to influence depression in persons who have been exposed to a number of stressful life events.
|
19016667 |
2009 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The serotonin transporter gene (SLC6A4) promoter polymorphism (5-HTTLPR) has been associated with depression, but most consistently in the context of environmental stress.
|
17460615 |
2008 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Human studies have suggested an association between a variable length polymorphism in the serotonin transporter gene promoter region and vulnerability to anxiety and depression.
|
17931429 |
2007 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The short (s) variant of the 5-HTT promoter polymorphism has been associated with an increased likelihood of depression after significant life stress and greater emotional reactivity to fear-invoking stimuli.
|
17766691 |
2007 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression.
|
16946185 |
2006 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A deletion/insertion polymorphism within the 5-HT transporter (5-HTT) promoter gene (5-HTT gene-linked polymorphic region, 5-HTTLPR) is thought to be associated with several psychopathological phenotypes related to disturbed impulse control, anxiety and depression.
|
15211560 |
2004 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, measures of the quality and availability of social supports were found to moderate risk for depression associated with a history of maltreatment and the presence of the short (s) allele of the serotonin transporter gene promoter polymorphism (5-HTTLPR).
|
15563601 |
2004 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism in the human serotonin transporter gene promoter (5-HTTLPR) is associated with anxiety and increased risk for developing depression in the face of adversity.
|
15302939 |
2004 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression.
|
12090814 |
2002 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies suggest that the short allele of the 5-HTT promoter (5-HTTPR) site can adversely influence the antidepressant response to SSRIs, and is associated with anxiety-related traits, depression, and impulsive disorders such as alcohol abuse.
|
12083964 |
2001 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The relationship of the serotonin transporter gene promoter region polymorphism (5-HTTLPR) to antidepressant response was examined in 95 elderly patients receiving a protocolized treatment for depression with paroxetine or nortriptyline.
|
11027924 |
2000 |
|
LOC110806262
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mosaicism for a serotonin transporter gene promoter-associated deletion: decreased recombination in depression.
|
10651116 |
1999 |
|
LOC110806262
|
0.100 |
Biomarker
|
disease |
BEFREE |
Even though other factors may be implicated, genotyping at 5-HTT promoter may represent a promising tool to individualize the pharmacological treatment of depression.
|
9857976 |
1998 |