| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.520 | AlteredExpression | disease | BEFREE | TC-IBS showed a pronounced depression phenotype with increased corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 expression at the frontal cortex and increased serum ACTH concentration. | 31570003 | 2019 | ||||
|
0.520 | Biomarker | disease | RGD | Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders. | 20860876 | 2011 | ||||
|
0.520 | Biomarker | disease | PSYGENET | Our results support an involvement of CRF receptors in the development of depression, such that elevated hippocampal CRF1 activity, in the absence of CRF2, produces a depression-dominated phenotype through the activation of the MEK/ERK pathway. | 18843268 | 2009 | ||||
|
0.520 | GeneticVariation | disease | BEFREE | Our aim was to investigate the influence of genetic variants in CRHR1, CRHR2, CRH-BP and FKBP5 genes on both the vulnerability for depression and the response to antidepressant treatment. | 17467808 | 2007 | ||||
|
0.520 | Biomarker | disease | PSYGENET | Our aim was to investigate the influence of genetic variants in CRHR1, CRHR2, CRH-BP and FKBP5 genes on both the vulnerability for depression and the response to antidepressant treatment. | 17467808 | 2007 | ||||
|
0.520 | Biomarker | disease | PSYGENET | The resulting chimeric peptide, [Glu(21),Ala(40)][Svg(1-12)]x[human/rat CRF(14-30)]x[Svg(30-40)], named cortagine, was analyzed pharmacologically in cell culture by using human embryonic kidney-293 cells transfected with cDNA coding for CRF(1) or CRF(2), in autoradiographic experiments, and in behavior experiments using male C57BL/6J mice for its modulatory action on anxiety- and depression-like behaviors with the elevated plus-maze test and the forced swim test (FST), respectively. | 15192151 | 2004 | ||||
|
0.520 | Biomarker | disease | PSYGENET | Male and female CRFR2-mutant mice showed increased immobility as an indicator of depression compared with wild-type mice of the same sex. | 12832554 | 2003 |