Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.330 | Biomarker | disease | BEFREE | The 5-HT7 receptor has been shown to be involved in stress reduction, depression, and nociceptive control. | 28901854 | 2018 | ||||
|
0.330 | Biomarker | disease | PSYGENET | The present study investigated the potential therapeutic utility of combining a 5-HT7 antagonist with a selective serotonin (5-HT) reuptake inhibitor (SSRI), the standard of care in depression, on circadian rhythm regulation. | 23276605 | 2013 | ||||
|
0.330 | Biomarker | disease | PSYGENET | The serotonin 5-HT(7) receptor has been linked to various psychiatric disorders, including schizophrenia, anxiety and depression, and is antagonized by antipsychotics such as risperidone, clozapine and lurasidone. | 22843252 | 2012 | ||||
|
0.330 | Biomarker | disease | PSYGENET | The data furthermore support the hypothesis that the 5-HT(7) receptor might be a suitable target for treating depression. | 20097233 | 2010 | ||||
|
0.330 | Biomarker | disease | BEFREE | There is a considerable amount of evidence supporting a role for the 5-HT(7) receptor in depression. | 19649616 | 2009 | ||||
|
0.330 | Biomarker | disease | PSYGENET | There is a considerable amount of evidence supporting a role for the 5-HT(7) receptor in depression. | 19649616 | 2009 | ||||
|
0.330 | Biomarker | disease | PSYGENET | As roles for 5-HT7 receptors in anxiety and depression were recently established, the current findings have implications for understanding the high anxiety and depressive-like phenotype of SERT-deficient mice. | 18712364 | 2008 | ||||
|
0.330 | Biomarker | disease | BEFREE | Although the biological functions of the 5-HT(7)Rs are poorly understood, preliminary evidence suggests that it may be involved in depression, control of circadian rhythms, and relaxation of vascular smooth muscles. | 15032609 | 2004 |