Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 GeneticVariation disease BEFREE Interestingly, the DISC1 gene mutation is linked to schizophrenia and depression. 31601402 2019
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 Biomarker disease CTD_human DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders. 29643356 2018
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 Biomarker disease BEFREE We report the novel regulation of proteolytic processing of amyloid precursor protein (APP) by DISC1, a major risk factor for psychiatric illnesses, such as depression and schizophrenia. 25224257 2015
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 Biomarker disease BEFREE We aimed to investigate whether DISC1 differentially modulates brain function during executive and memory processing, and morphology in regions relevant for depression and anxiety disorders (affective disorders). 25533973 2015
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 Biomarker disease PSYGENET We aimed to investigate whether DISC1 differentially modulates brain function during executive and memory processing, and morphology in regions relevant for depression and anxiety disorders (affective disorders). 25533973 2015
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 Biomarker disease PSYGENET Overall, we find neurobiological changes accompanying social anhedonia in the NAC of DISC1-Q31L mutant mice, consistent with a role for DISC1 in regulating social reward as an endophenotype of depression. 23011268 2013
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 Biomarker disease PSYGENET Twenty-two human brain imaging studies have examined the influence of DISC1 variants in health, schizophrenia, bipolar disorder or depression. 23602339 2013
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 Biomarker disease PSYGENET A recent study reported that N-ethyl-N-nitrosourea (ENU)-induced mutations in exon 2 of the mouse Disc1 gene, which resulted in the amino acid exchange of Q31L and L100P, caused an increase in depression-like behavior in 31 L mutant mice and schizophrenia-like behavior in 100P mutant mice; thus, these are potential animal models of psychiatric disorders. 22348257 2012
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 Biomarker disease PSYGENET Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co-segregates with schizophrenia, bipolar disorder and depression. 22547224 2012
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 GeneticVariation disease BEFREE Disrupted-In-Schizophrenia 1 (DISC1) was identified as a risk factor for psychiatric illness through its disruption by a balanced chromosomal translocation, t(1;11)(q42.1;q14.3), that co-segregates with schizophrenia, bipolar disorder and depression. 22547224 2012
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 GeneticVariation disease BEFREE Cognitive measures of working memory (rs2793094, P=3.38 × 10(-4)), as well as lifetime history of depression (rs4658966, P=4.33 × 10(-4); rs12137417, P=4.93 × 10(-4)) and panic (rs12137417, P=7.41 × 10(-4)) were associated with DISC1 sequence variation. 21483430 2011
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 GeneticVariation disease BEFREE Disrupted-in-Schizophrenia-1 (DISC1) is a genetic susceptibility locus for major mental illness, including schizophrenia and depression. 22832659 2011
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 Biomarker disease BEFREE Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. 19255581 2010
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 GeneticVariation disease BEFREE These data are consistent with: (i) the high frequency of depression in the large Scottish family with a translocation disrupting DISC1; (ii) linkage disequilibrium analysis demonstrating haplotypes associated with relatively small increases in risk for bipolar disorder (<3-fold odds ratio). 20850505 2010
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 GeneticVariation disease BEFREE This study demonstrates that Disc1 missense mutations in mice give rise to phenotypes related to depression and schizophrenia, thus supporting the role of DISC1 in major mental illness. 17481393 2007
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.600 Biomarker disease BEFREE Altered DISC1-PDE4B interaction may thus underlie the symptoms of some cases of schizophrenia and depression. 17823207 2007