Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 Biomarker disease BEFREE These findings suggest that selective inhibition of COX-2 ameliorates depression-like behaviors in rat models of depression. 31539536 2019
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 AlteredExpression disease BEFREE 1 L-1β, TNF-α and COX-2), increased BDNF expression and neurogenesis, restored the dysfunction of ATP production and oxidative stress in inflammation- induced depression. 31022424 2019
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 Biomarker disease BEFREE Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression. 28108057 2018
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 Biomarker disease BEFREE Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression. 30526621 2018
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 Biomarker disease PSYGENET There is also some evidence indicative of a role of genetic variants of the enzymes, Cyclo-oxygenase2 (COX-2) and Phospholipase2 (PLA2), in the aetiology of depression. 22580182 2013
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 Biomarker disease BEFREE There is also some evidence indicative of a role of genetic variants of the enzymes, Cyclo-oxygenase2 (COX-2) and Phospholipase2 (PLA2), in the aetiology of depression. 22580182 2013
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 Biomarker disease PSYGENET The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder. 22331023 2012
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 Biomarker disease PSYGENET Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis. 21655952 2012
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 GeneticVariation disease BEFREE Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis. 21655952 2012
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 Biomarker disease PSYGENET Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels. 20034614 2010
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 Biomarker disease PSYGENET Functional polymorphism of cyclooxygenase-2 gene (G-765C) in depressive patients. 20588070 2010
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 AlteredExpression disease BEFREE COX-2 overexpression was observed in 12 of 77 (15.6%) DP and there was no significant difference between DPdep (3 of 23, 13.0%) and DPpo (9 of 54, 16.7%). 12397273 2002
Entrez Id: 4513
Gene Symbol: COX2
COX2
0.470 Biomarker disease HPO