| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | This review describes (1) different 5-HT functioning in the embryonic (as neurotrophin) and adult brain (as a neurotransmitter); (2) BDNF as a modulator of 5-HT system and vice versa; (3) the prolonged positive effect of BDNF on genetically and epigenetically defined central nervous system disorders; (4) The 5-HT-BDNF interplay contribution to aggressive behavior, depression, drug addiction, suicide, and stress response; and (5) the role of common second messengers for 5-HT and BDNF signaling in the 5-HT-BDNF interaction. | 30661441 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | Furthermore, similar trends were observed in CHD patients with depression in terms of irisin, adropin and BDNF as compared with CHD patients without depression (P=0.006; P=0.003; P=0.002; respectively). | 31475168 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | The article reflects on the current literature on the role of BDNF as a promising therapeutic target in the treatment of depression and on the current advances in the development of small molecules on the base of this neurotrophin as potential antidepressants. | 30931847 | 2019 | ||||
|
0.070 | Biomarker | disease | BEFREE | This article presents a review of BDNF as a neurobiological marker for schizophrenia and depression and for the efficacy of rTMS treatments of these mental diseases. | 30586536 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | In this study, we evaluated the effect of anti-BDNF and anti-proBDNF in the ACC on the CUMS-induced depression mice. | 27957676 | 2017 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | A single-nucleotide polymorphism in the BDNF gene (BDNFVal66Met), associated with depression and anxiety, has been proposed as a genetic risk factor for CVD. | 26705390 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Converging lines of evidence point to brain-derived neurotrophic factor (BDNF) as a factor in the pathophysiology of depression. | 15918078 | 2005 |