Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE T<sub>H</sub>2 chemokines (CCL13, CCL17) were consistently elevated in patients with AD across all ages (P < .05), whereas T<sub>H</sub>1 (CXCL10) and T<sub>H</sub>17 (KYNU, CCL20) markers incrementally increased with age in both patients with AD and healthy subjects. 31622668 2020
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE CXCL8, CCL2 and CCL17 showed an association with objective SCORing Atopic Dermatitis score. 29989151 2019
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE IL-4 Augments IL-31/IL-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic Cells: Implications for Atopic Dermatitis. 31434203 2019
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE Identified biomarkers of AD severity included T helper 2-skewed markers [interleukin (IL)-13, CCL17, CCL22, IL-5]; markers of innate activation (IL-18, IL-1α, IL1β, CXCL8) and angiogenesis (Flt-1, vascular endothelial growth factor); and others (soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, IL-16, IL-17A). 30132823 2019
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE Among the biomarkers tested, serum SCCA2 also showed the best correlations with clinical AD severity and TARC and showed the best diagnosability for AD in ROC analysis. 31378660 2019
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 AlteredExpression disease BEFREE Consistently, the frequency of TIGIT<sup>+</sup> cells among CD4<sup>+</sup> T cells was negatively correlated with both serum thymus and activation-regulated chemokine levels and immunoglobulin E levels in patients with AD. 30402886 2019
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE We found that AD S. aureus<sup>+</sup> patients had more severe disease based on all scoring systems except itch (Numerical Rating Scale), and they had higher levels of type 2 biomarkers (eosinophil count, tIgE, CCL17, and periostin). 29604251 2018
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 AlteredExpression disease BEFREE Laboratory data for CIE and AD were similar, but serum levels of thymus and activation-regulated chemokine (TARC), a T-helper (Th) 2 cytokine, in the CIE group were significantly more elevated than in the AD group. 29590497 2018
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 AlteredExpression disease BEFREE SP treatment significantly reduced the infiltration of mast cells and CD3-positive T cells as well as inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and thymic stromal lymphopoietin (TSLP), in AD-like skin lesions and decreased the levels of IgE and thymus and activation-regulated chemokine in serum. 28833499 2018
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE These findings indicate that Glyteer may exhibit therapeutic potential for AD by downregulating the CCL17 and CCL22 production from DCs in a Th2-deviated microenvironment. 29649105 2018
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE In this study, we report that Lactobacillus strains have a significant suppressive effect on tumour necrosis factor (TNF)-α-induced expression and production of thymus and activation-regulated chemokine (TARC), a T helper 2 cell chemokine responsible for atopic dermatitis, in human keratinocytes. 29798706 2018
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 GeneticVariation disease BEFREE Increases in serum cytokines and chemokines (IL-13, IL-22, CCL17) were found in AD versus healthy individuals and were reduced with treatment. 27825969 2017
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE Levels of inflammatory cytokines and chemokines, such as thymus- and activation-regulated chemokine (TARC), macrophage-derived chemokine, and thymic stromal lymphopoietin (TSLP), were examined in human keratinocytes supplemented with or without CTP under AD-like inflammation. 29017796 2017
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 GeneticVariation disease BEFREE We identified unique signatures for AD (Immunoglobulin E (IgE), thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC)), CD (10 proteins), and PS (kynureninase (KYNU)). 28703865 2017
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 GeneticVariation disease BEFREE They produced both AD (CCL17/18/22) and maturation-related (CCL3/4/5) chemokines at higher level than controls. 27701668 2017
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE Th2-related chemokines such as thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22), and pro-inflammatory cytokines including interleukin (IL)-1β and IL-6 are considered to play a crucial role in AD. 28958612 2017
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE Oral administration of L. chungangensis CAU 28(T) suppressed the production of IL-4, IL-5, IL-12, IFN-γ, tumor necrosis factor-α, and thymus- and activation-regulated chemokine (TARC) in skin lesions, indicating that it strongly drives the local immune system with efficacy comparable to that of tacrolimus, a topical immunomodulatory drug used for the treatment of atopic dermatitis. 27289147 2016
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE We aimed to investigate the effects of DHE-Glc, a synthetic molecule derived from ergosterol, on AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) in mice and to elucidate the effects of DHE-Glc on TNF-α/IFN-γ-induced production of CCL17 and CCL22 in human keratinocytes (HaCaTs) and DNCB induced skin inflammation mice model. 26100037 2015
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE The Th9 cell percentage, PU.1 and IL-9 expression levels of AD patients were all increased significantly compared with the other two control groups (P < 0·01), and correlated positively with SCORing Atopic Dermatitis index, serum immunoglobulin (Ig)E and thymus- and activation-regulated chemokine (TARC) levels (P < 0·05). 24032555 2014
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE Chemokines are important mediators of cell migration, and thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22) are well-known typical inflammatory chemokines involved in atopic dermatitis (AD). 24704449 2014
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 AlteredExpression disease BEFREE These results suggest that CG inhibited the development of the AD-like skin symptoms by modulating Th1 and Th2 responses in the skin lesions in mice and TARC expression by suppressing TNF-α/IFN-γ-induced NF-κB activation in keratinocytes, and so may be a useful tool in the therapy of AD-like skin symptoms. 23454147 2013
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE We examined plasma LIGHT levels, total serum IgE, serum value of CCL17 and peripheral blood eosinophil counts in patients with AD and healthy subjects. 22519595 2012
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 Biomarker disease BEFREE Recent clinical studies have shown important roles of the Th2 chemokines, CCL22 and CCL17 in the pathogenesis of AD. 22125604 2011
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 AlteredExpression disease BEFREE Among several cytokines and chemokines produced in the skin, CCL17, which is highly expressed in AD, was found to be a strong inducer of AQP3 expression and enhanced keratinocyte proliferation. 21191421 2011
Entrez Id: 6361
Gene Symbol: CCL17
CCL17
0.400 AlteredExpression disease BEFREE A minor CCL17 mRNA increase was measured in lesional psoriatic skin.No alterations were found in AD. 21707761 2011