Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 Biomarker disease BEFREE These findings suggest that IL-4 mediates IL-31RA expression and IL-31/IL-31RA interaction augments Ccl 17 and Ccl 22 production in BMDCs, which promotes Th2-deviated immune response in AD. 31434203 2019
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 AlteredExpression disease BEFREE Eosinophil and Th2 markers (IL5RA, IL1RL1/ST2, HRH4, CCR3, SIGLEC8, PRSS33, CLC from gene arrays; IL13/IL4/CCL22 from RT-PCR) were up-regulated in early pediatric AD blood, whereas IFNG/Th1 was decreased. 30508584 2019
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 Biomarker disease BEFREE These findings indicate that Glyteer may exhibit therapeutic potential for AD by downregulating the CCL17 and CCL22 production from DCs in a Th2-deviated microenvironment. 29649105 2018
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 Biomarker disease BEFREE In adults, the clinical severity of AD has been associated with increases in T helper cell type (Th) 2, Th22, and Th17 serum markers, including high levels of CC chemokine ligand (CCL) 17 and CCL22 chemokines. 29966024 2018
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 AlteredExpression disease BEFREE Decreased interferon (IFN)-γ levels and increased levels of macrophage-derived chemokine (MDC) and intercellular adhesion molecule (ICAM)-1 are known to be involved in allergic skin diseases, such as eczema and atopic dermatitis. 29218605 2018
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 Biomarker disease BEFREE Th2-related chemokines such as thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22), and pro-inflammatory cytokines including interleukin (IL)-1β and IL-6 are considered to play a crucial role in AD. 28958612 2017
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 GeneticVariation disease BEFREE We identified unique signatures for AD (Immunoglobulin E (IgE), thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC)), CD (10 proteins), and PS (kynureninase (KYNU)). 28703865 2017
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 Biomarker disease BEFREE Levels of inflammatory cytokines and chemokines, such as thymus- and activation-regulated chemokine (TARC), macrophage-derived chemokine, and thymic stromal lymphopoietin (TSLP), were examined in human keratinocytes supplemented with or without CTP under AD-like inflammation. 29017796 2017
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 Biomarker disease BEFREE We aimed to investigate the effects of DHE-Glc, a synthetic molecule derived from ergosterol, on AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) in mice and to elucidate the effects of DHE-Glc on TNF-α/IFN-γ-induced production of CCL17 and CCL22 in human keratinocytes (HaCaTs) and DNCB induced skin inflammation mice model. 26100037 2015
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 Biomarker disease BEFREE Chemokines are important mediators of cell migration, and thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22) are well-known typical inflammatory chemokines involved in atopic dermatitis (AD). 24704449 2014
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 Biomarker disease CTD_human To investigate whether polymorphisms of the CCL22 gene affect the susceptibility to AD, we conducted association studies and functional studies of the related variants. 22125604 2011
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 GeneticVariation disease BEFREE To investigate whether polymorphisms of the CCL22 gene affect the susceptibility to AD, we conducted association studies and functional studies of the related variants. 22125604 2011
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 Biomarker disease CTD_human Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis. 18249437 2008
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 Biomarker disease BEFREE These data suggest that the CCL22 level produced by MoDCs thus reflects the disease activity of AD and it may also play an important role regarding the production of CCL22 in the pathogenesis of AD. 17008059 2006
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 AlteredExpression disease LHGDN These data suggest that the CCL22 level produced by MoDCs thus reflects the disease activity of AD and it may also play an important role regarding the production of CCL22 in the pathogenesis of AD. 17008059 2006
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 AlteredExpression disease LHGDN The serum levels of TARC, MDC, eotaxin and IgE appeared to be significantly higher in patients with AD than in healthy people. 15813816 2005
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 AlteredExpression disease LHGDN The purpose of this study was to investigate serum levels of Th2 chemokines TARC and MDC and a Th1 chemokine Mig in the same samples from patients with AD and their clinical correlation. 15113590 2004
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 Biomarker disease LHGDN Furthermore, we found that TARC and MDC levels are significantly increased in the sera obtained from patients with atopic dermatitis, and that the amounts are correlated with the severity of atopic dermatitis. 12715916 2003
Entrez Id: 6367
Gene Symbol: CCL22
CCL22
0.400 Biomarker disease BEFREE Here we demonstrated MDC immunoreactivity in the epidermal layer of AD skin at levels stronger than that of TARC. 12096036 2002