Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE There is accumulating evidence that the AGEs-RAGE interaction plays an important role in accelerated atherosclerosis in diabetes. 31378770 2019
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 AlteredExpression disease BEFREE Our data demonstrate that RAGE ligand levels reflect disease severity and extent in TB-DM, distinguish KDM from NDM and are modulated by metformin therapy. 31818258 2019
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE Receptor for advanced glycation end-products (RAGE) has been linked to the pathogenesis of both the macrovascular and microvascular complications of diabetes. 31492153 2019
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE The present investigation aims to evaluate the protective potential of FPS-ZM1, a selective inhibitor of receptor for advanced glycation end products (RAGE), alone and in combination with valsartan, an angiotensin receptor blocker, against glomerular injury parameters in streptozotocin-induced diabetic rats.FPS-ZM1 at 1 mg/kg (i.p.), valsartan at 100 mg/kg (p.o.), and their combination were administered for 4 weeks, starting 2 months after diabetes induction in rats. 29948786 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 AlteredExpression disease BEFREE Through the detection of protein expression, EGCG was observed to possess the ability to downregulate the accumulation of AGE-RAGE in pancreatic tissues as well as in the transcription factor nuclear factor-κB (NF-κB), which represents a potentially significant method by which EGCG influences diabetes. 30582209 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE Extracellular matrix glycation and receptor for advanced glycation end-products activation: a missing piece in the puzzle of the association between diabetes and cancer. 29373651 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE Receptor for advanced glycation end products (RAGE) is a multiligand receptor belonging to the immunoglobulin superfamily and plays crucial roles in the development of many human diseases such as neurodegenerative diseases, diabetes, cardiovascular diseases, osteoarthritis and cancer. 29477598 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE The receptor for advanced glycation end-products (RAGE) is implicated in multiple disease states such as cancer, diabetes and neurodegenerative disorders, and RAGE inhibitors are being explored as potential new therapies in such cases. 30613302 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE Irbesartan attenuates advanced glycation end products-mediated damage in diabetes-associated osteoporosis through the AGEs/RAGE pathway. 29702126 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 AlteredExpression disease BEFREE High mobility group protein B1 (HMGB1) is a RAGE (also known as AGER) agonist whose levels are increased in diabetes and that contributes to pain by modulating peripheral inflammatory responses. 29930087 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE These AGE molecules bind to their respective receptors called the receptor for advanced glycation end products (RAGE) and initiate several aberrant signaling pathways leading to onset of diseases such as diabetes, Alzheimer's, atherosclerosis, heart failure and cancer. 28546110 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 AlteredExpression disease BEFREE We observed an overexpression of RAGE in lesional samples of patients with ARPC which was independent of the presence of diabetes. 28474638 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE Collectively, these data implicate DIAPH1 in the pathogenesis of diabetes-associated nephropathy and suggest that the RAGE-DIAPH1 axis is a logical target for therapeutic intervention in this disorder. 30132346 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE The role of advanced glycation end products (AGEs) and its C-terminal truncated receptor (soluble receptor for advanced glycation end products, sRAGE) in ST-segment elevation myocardial infarction (STEMI) patients with or without diabetes is unknown. 30045252 2018
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE Activation of the receptor for advanced glycation end products (RAGE) and its ligands has been suggested to participate in chronic disorders such as diabetes and its complications. 28099448 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE Two-week infusion of RAGE-aptamer just after the induction of diabetes also inhibited the AGE-RAGE-oxidative stress system and MCP-1 levels in the kidneys of 8-week-old diabetic rats and simultaneously ameliorated podocyte injury and albuminuria. 28385802 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE Advanced glycation end products generated by chronic hyperglycemia and their receptor RAGE provide critical links between diabetes and AD. 27156888 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE Since reduced HMGB1 binds to RAGE but not to TLR4, redox modification of HMGB1 as a mechanism regulating the cross-talk between apoptosis and autophagy in diabetes is discussed. 28695466 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE Sugar makes neutrophils RAGE: linking diabetes-associated hyperglycemia to thrombocytosis and platelet reactivity. 28504654 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 AlteredExpression disease BEFREE It is the activation of RAGE during GNB infections in those with diabetes that accounts for their heightened susceptibility to infection compared to nondiabetic hosts. 28830942 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE We serially evaluated experimental DPN in male and female wild-type mice and male RAGE null (RN) mice, each with nondiabetic controls, during 16 wk of diabetes, the final 8 wk including groups given intranasal insulin. 28223295 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE Streptozotocin was used to induce diabetes in both wild type and RAGE knockout mice. 27869797 2017
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE Advanced glycation end products impair the functions of saphenous vein but not thoracic artery smooth muscle cells through RAGE/MAPK signalling pathway in diabetes. 27297874 2016
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 GeneticVariation disease BEFREE We found that Gly82Ser in RAGE showed significant association with DR. More studies with larger sample sizes that control for important risk factors, such as duration of diabetes, are needed to validate our findings. 27684793 2016
Entrez Id: 177
Gene Symbol: AGER
AGER
0.100 Biomarker disease BEFREE The Cox regression model validated four significant variables associated with microalbuminuria: RAGE 374AA (HR 4.19 [1.84-9.58] (p = 0.001)), CYBA TT+TC (HR 2.1 [1.16-3.80], p = 0.015), male sex (HR 1.92 [1.07-3.43], p = 0.028) and diabetes diagnosis at the pediatric stage (HR 1.85 [1.03-3.32], p = 0.039). 26607824 2016