| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | The percentages of CC, CT and TT genotypes at 69 position of ABCA1 gene were 31.63%, 58.16% and 10.21% in control as well as 22.54%, 69.60% and 7.86% in diabetes group respectively. | 30529097 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | There was no association of ABCA1 C69T gene polymorphisms with the risk of diabetes. | 31010439 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Serum capacity to induce ABCA1-mediated cholesterol efflux was impaired in the diabetic group (p < 0.01) and cholesterol efflux correlated with pre-β1 HDL (Pearson's r = 0.38, p < 0.01), and this association remained significantly even after controlling for age, gender, body mass index, diabetes status, smoking, apoA1, triglyceride and LDL. | 28595104 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | In the present study, the effects of metabolites of diabetes and ischemia were observed on PBMNC ABCA1 protein and thus on HDL-C in AMI patients. | 24796288 | 2015 | ||||
|
0.080 | Biomarker | disease | BEFREE | ABCA1 was decreased in all the risk populations except diabetes and male. | 22614118 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | The ABCA1 pathway has therefore become a promising new therapeutic target for treating cardiovascular disease and diabetes. | 19344785 | 2009 | ||||
|
0.080 | Biomarker | disease | BEFREE | Recently, it has been reported that ABCA1 is expressed in pancreatic beta cells and mice with specific inactivation of ABCA1 in beta cells showed markedly impaired insulin secretion, suggesting that ABCA1 deficiency may be involved in diabetes. | 19556721 | 2009 | ||||
|
0.080 | Biomarker | disease | BEFREE | Metabolites elevated in individuals with the metabolic syndrome and diabetes destabilize ABCA1 protein and decrease cholesterol export from macrophages. | 16183915 | 2005 |