Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 Biomarker disease BEFREE Sulfonylureas continue to be an effective, sustainable, and safe treatment for KCNJ11-related diabetes. 31250216 2019
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE The aim of this study was to ascertain the polymorphic markers profile of ADIPOQ, KCNJ11 and TCF7L2 genes in Kyrgyz population and to analyze the association of polymorphic markers and combinations of ADIPOQ gene's G276T locus, KCNJ11 gene's Glu23Lys locus and TCF7L2 gene's VS3C>T locus with type two diabetes (T2D) in Kyrgyz population. 30467975 2019
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192). 31823921 2019
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Evaluating a combined cohort of ARIC and JHS participants, we sought to determine if KCNJ11 variants are risk factors for diabetes; and if KCNJ11 variants modify the association between serum K and diabetes risk. 30169531 2018
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE A 22-year-old woman was found to have a KCNJ11 mutation (G334V) following diagnosis with diabetes at 3 weeks. 29896782 2018
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Results The dominant (EE v EK + KK, p = 0.022) and additive (EK v EE + KK, p = 0.021) models, but not the recessive model (KK v EE + EK, p = 0.727) of KCNJ11 were linked to diabetes. 29893194 2018
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Polymorphism E23K (rs5219) in the KCNJ11 gene in Euro-Brazilian subjects with type 1 and 2 diabetes. 28387875 2017
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 Biomarker disease BEFREE Pancreatic autopsy tissue sections from a 2-year-old female child diagnosed with KCNJ11-related diabetes at 4 days of age and 13 age-matched controls were stained with insulin, glucagon, somatostatin, pancreatic polypeptide, and Ki67 antibodies to determine islet endocrine cell composition and area. 27802092 2017
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk. 27118464 2016
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 Biomarker disease BEFREE This series represents the largest and most comprehensive study of neuropsychological and behavioural dysfunction of individuals with KCNJ11 diabetes and is the first to compare outcome with sibling controls. 27223594 2016
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Monogenic mutations, such as those in the potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) and insulin (INS) genes, are identified in young patients with type 1B diabetes (non-autoimmune-mediated). 27398945 2016
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes. 27033559 2016
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Diabetes susceptibility in Mayas: Evidence for the involvement of polymorphisms in HHEX, HNF4α, KCNJ11, PPARγ, CDKN2A/2B, SLC30A8, CDC123/CAMK1D, TCF7L2, ABCA1 and SLC16A11 genes. 25839936 2015
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE NODAT is a polygenic disease and KCNJ11 E23K polymorphism is considered as a diabetes-susceptibility gene. 24996284 2014
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE The patient with KCNJ11 G366W mutation suffered only type 1B diabetes, without neurological developmental abnormalities. 24698822 2014
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Functional characterization of a novel KCNJ11 in frame mutation-deletion associated with infancy-onset diabetes and a mild form of intermediate DEND: a battle between K(ATP) gain of channel activity and loss of channel expression. 23667671 2013
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Our results suggest that genetic diagnosis for the KCNJ11 mutations in familial early-onset type 2 diabetes mellitus may help in understanding the molecular aetiology and in providing more personalised treatment for these specific forms of diabetes in Chinese and other Asian patients. 24018988 2013
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE We observed suggestive associations with the diabetes risk variant rs7961581 (p = 0.038; between TSPAN8 and LGR5) and rs5215 (p = 0.043; KCNJ11), the LDL risk variant rs11206510 (p = 0.045; PCSK9), as well as the AF risk locus ZFHX3. 24135527 2013
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Identification of INS and KCNJ11 gene mutations in type 1B diabetes in Japanese children with onset of diabetes before 5 years of age. 22957706 2013
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE The KCNJ11 and ABCC8 genes were sequenced in 115 infants with permanent diabetes diagnosed between 6 and 12 months and in 405 patients presenting before 6 months. 21981029 2012
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 Biomarker disease BEFREE Neurodevelopmental disability in KCNJ11-related diabetes includes visuomotor problems that may be ameliorated by early sulfonylurea treatment. 22855734 2012
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Only one mutation (p.Glu227Lys in KCNJ11) co-segregated with diabetes in the family (with a LOD-score of 3.68). 22701567 2012
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus. 22264780 2012
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 Biomarker disease BEFREE KCNJ11 should be considered as the etiology of diabetes even beyond the neonatal period if present in combination with negative autoantibody testing and even mild neurological symptoms. 22694282 2012
Entrez Id: 3767
Gene Symbol: KCNJ11
KCNJ11
0.100 GeneticVariation disease BEFREE Neonatal diabetes mellitus (NDM) due to KCNJ11 gene mutation presents with diabetes in the first 3 months of life and sometimes with neurological features like developmental delay, muscle weakness and epilepsy. 21210267 2011