Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5080
Gene Symbol: PAX6
PAX6
0.350 Biomarker disease BEFREE A 484-630 kb deletion ∼120 kb distal to PAIRED BOX 6 (PAX6) showed dominant cosegregation with aniridia and diabetes in all affected family members. 30572005 2019
Entrez Id: 5080
Gene Symbol: PAX6
PAX6
0.350 GeneticVariation disease BEFREE To determine the ability of these elements to regulate gene expression, synthetic transcriptional activators and repressors were targeted to PE3 and PE4, modulating Pax6 gene expression, as well as influencing neighbouring genes and long non-coding RNAs, implicating the Pax6 locus in pancreas function and diabetes. 30007277 2018
Entrez Id: 5080
Gene Symbol: PAX6
PAX6
0.350 GeneticVariation disease BEFREE PAX6 mutation in association with ptosis, cataract, iris hypoplasia, corneal opacification and diabetes: a new variant of familial aniridia? 23566044 2013
Entrez Id: 5080
Gene Symbol: PAX6
PAX6
0.350 AlteredExpression disease BEFREE Disturbed islet architecture has been proposed as the reason why mice with complete inactivation of paired box 6 (PAX6) in the pancreas develop diabetes. 19034419 2009
Entrez Id: 5080
Gene Symbol: PAX6
PAX6
0.350 GeneticVariation disease BEFREE Although we did not detect a mutation within the characterized portion of the PAX6 gene in one of the five aniridia patients, diabetes was cosegregated with aniridia in her family, and a single nucleotide polymorphism in intron 9 of the PAX6 gene was correlated with the disorders, suggesting that a mutation, possibly located in an uncharacterized portion of the PAX6 gene, can explain both diabetes and aniridia in this family. 11756345 2002
Entrez Id: 5080
Gene Symbol: PAX6
PAX6
0.350 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 26060
Gene Symbol: APPL1
APPL1
0.330 Biomarker disease BEFREE Thus, we investigated whether APPL1 prevents beta cell apoptosis and inflammation in diabetes. 28011992 2017
Entrez Id: 26060
Gene Symbol: APPL1
APPL1
0.330 Biomarker disease BEFREE A deep understanding of APPLs and their related signaling pathways may potentially lead to therapeutic and interventional treatments for obesity, diabetes, cancer and neurodegenerative diseases. 28108259 2017
Entrez Id: 26060
Gene Symbol: APPL1
APPL1
0.330 GeneticVariation disease BEFREE These findings-linking APPL1 mutations to familial forms of diabetes-reaffirm the critical role of APPL1 in glucose homeostasis. 26073777 2015
Entrez Id: 26060
Gene Symbol: APPL1
APPL1
0.330 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 1968
Gene Symbol: EIF2S3
EIF2S3
0.310 Biomarker disease GENOMICS_ENGLAND EIF2S3 Mutations Associated with Severe X-Linked Intellectual Disability Syndrome MEHMO. 28055140 2017
Entrez Id: 1968
Gene Symbol: EIF2S3
EIF2S3
0.310 GeneticVariation disease BEFREE PERK mutations are associated with the Wolcott-Rallison syndrome of infantile diabetes and mutations that prevent the alpha-subunit of eIF2 from being phosphorylated by PERK, block beta-cell development, and impair gluconeogenesis. 12475790 2002
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.200 GeneticVariation disease BEFREE There is a trend toward an association between faster GE and the diabetes-associated allele at rs7903146 in TCF7L2. 31691451 2020
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.200 GeneticVariation disease BEFREE Age (OR: 1.07; 95% CI: 1.03, 1.10), male sex (OR: 1.95; 95% CI: 1.68, 2.23), hypertension (OR: 2.11; 95% CI: 1.64, 2.58), diabetes (OR: 1.95; 95% CI: 1.33, 2.57), body mass index (OR: 1.04; 95% CI: 1.03, 1.05), smoking (OR: 1.71; 95% CI: 1.30, 2.12), elevated lipoprotein(a) (OR: 1.90; 95% CI: 1.10, 2.71), low high-density lipoprotein cholesterol (OR: 1.39; 95% CI: 1.24, 1.53), and a family history of CVD (OR: 1.83, 95% CI: 1.58, 2.07) were found to be significant CVD risk factors in FH. 30527766 2020
Entrez Id: 79068
Gene Symbol: FTO
FTO
0.200 AlteredExpression disease BEFREE The association of dietary carbohydrate with FTO gene expression in visceral and subcutaneous adipose tissue of adults without diabetes. 30933732 2020
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.200 GeneticVariation disease BEFREE This study assessed associations of diet quality (evaluated using the Alternative Healthy Eating Index (AHEI)), and the interaction of diet quality with diabetes, on total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), apolipoprotein A (apoA1), and apolipoprotein B (apoB) among American Indians (AIs). 31804627 2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.200 GeneticVariation disease BEFREE Transcription factor 7-like 2 (TCF7L2), which previously known as TCF-4, is a major form of transcription factor involved in the downstream WNT signaling and exhibits the strongest association to diabetes susceptibility. 31312258 2019
Entrez Id: 79068
Gene Symbol: FTO
FTO
0.200 GeneticVariation disease BEFREE Additionally, both omentin Val109Asp and FTO rs9939609 polymorphisms were significantly positively correlated to familial history of diabetes (P = 0.046 and P = 0.024, respectively). 31200723 2019
Entrez Id: 79068
Gene Symbol: FTO
FTO
0.200 Biomarker disease BEFREE Mounting evidence indicated that FTO plays a critical role in occurrence, progression and treatment of various cancers, even acting as a cancer oncogene in acute myeloid leukaemia, research on which is no longer restricted to metabolic diseases such as obesity and diabetes. 30465076 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.200 AlteredExpression disease BEFREE After adjustment for age, gender, duration of diabetes, and BMI, multivariate analysis showed significant association of smoking (<i>p</i>=0.002) and HOMA-IR (<i>p</i>=0.003) with intraocular IL-6 levels, while intraocular VEGF and systemic Lp-A levels correlated significantly (<i>p</i>=0.032). 31396410 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.200 AlteredExpression disease BEFREE In this biracial cohort, elevated lipoprotein(a) levels in Caucasian individuals with diabetes or prediabetes were associated with further increased ASCVD risk. 30685442 2019
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.200 Biomarker disease BEFREE An Ang(1-7) secreting Lactobacillus paracasei (LP) or LP-A has been described for regulation of diabetes and hypertension; however, we are the first to our knowledge to propose this paradigm as it relates to aging. 31586210 2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.200 GeneticVariation disease BEFREE The aim of this study was to ascertain the polymorphic markers profile of ADIPOQ, KCNJ11 and TCF7L2 genes in Kyrgyz population and to analyze the association of polymorphic markers and combinations of ADIPOQ gene's G276T locus, KCNJ11 gene's Glu23Lys locus and TCF7L2 gene's VS3C>T locus with type two diabetes (T2D) in Kyrgyz population. 30467975 2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.200 Biomarker disease BEFREE Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. 31619789 2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
0.200 GeneticVariation disease BEFREE The transcription factor 7-like 2 (TCF7L2) gene confers one of the strongest genetic predispositions to type 2 diabetes, but diabetes development can be modified by diet. 31049566 2019