| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | group | BEFREE | Our method successfully identifies previously validated Cytomegalovirus and type one diabetes responsive TCR[Formula: see text] sequences . | 29533178 | 2018 | ||||
|
0.080 | Biomarker | group | BEFREE | We generated a novel double transgenic (Tg) mouse model on the naturally diabetes resistant C57Bl/6 background, co-expressing two transgenes including a specific TCR anti-lymphocytic choriomeningitis virus nucleoprotein (LCMV-NP) carried by CD8<sup>+</sup> T cells and LCMV-NP (as neo-self antigen) expressed by pancreatic beta cells. | 27683954 | 2016 | ||||
|
0.080 | Biomarker | group | BEFREE | We applied single-cell TCR α- and β-chain sequencing to peripheral blood GAD65-specific CD4(+) T cells, and TCR α-chain next-generation sequencing to bulk memory CD4(+) T cells to provide insight into TCR diversity in autoimmune diabetes mellitus. | 25681349 | 2015 | ||||
|
0.080 | Biomarker | group | BEFREE | We have found that RAGE is expressed intracellularly in human T cells following TCR activation but constitutively on T cells from patients with diabetes. | 22509345 | 2012 | ||||
|
0.080 | AlteredExpression | group | BEFREE | To study the immune tolerance and regulatory environment permissive for such autoreactive T cells, we expressed TCR transgenes derived from two autoreactive human T cells, 4.13 and 164, in HLA-DR4 transgenic mice on a C57BL/6-derived "diabetes-resistant" background. | 19535636 | 2009 | ||||
|
0.080 | GeneticVariation | group | BEFREE | Thus, a TCR CDR3beta sequence appears to be a common idiotope associated with mouse diabetes. | 10360969 | 1999 | ||||
|
0.080 | Biomarker | group | BEFREE | Young BDC2.5 TCR tg mice show insulitis but not diabetes; CY treatment provoked diabetes in 100% of animals with rapid, highly reproducible kinetics. | 9933106 | 1999 | ||||
|
0.080 | Biomarker | group | BEFREE | While the TCR repertoire in DM patients was generally polyclonal, an oligoclonal profile characterized PM patients. | 8133064 | 1994 |