Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8639
Gene Symbol: AOC3
AOC3
0.390 AlteredExpression group BEFREE Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively. 30022055 2019
Entrez Id: 8639
Gene Symbol: AOC3
AOC3
0.390 AlteredExpression group BEFREE A significantly decreased SSAO activity and plasma ET-1 level, as well as obviously increased plasma levels of MA and NO(x)- were observed in the DM + AG and DM + 2-BEA groups in comparison with the DM group (P < 0.01). 31182088 2019
Entrez Id: 8639
Gene Symbol: AOC3
AOC3
0.390 Biomarker group BEFREE VAP-1 has been strongly implicated in several pathological processes, including diabetes, inflammation, hypertension, hepatic steatosis and renal diseases, and is an important disease marker and therapeutic target. 29364582 2018
Entrez Id: 8639
Gene Symbol: AOC3
AOC3
0.390 Biomarker group BEFREE Vascular adhesion protein-1 (VAP-1) is secreted by vascular smooth muscle cells, adipocytes and endothelial cells with functional monoamine oxidase activity and is elevated in atherosclerosis, diabetes mellitus and obesity. 28044236 2017
Entrez Id: 8639
Gene Symbol: AOC3
AOC3
0.390 Biomarker group CTD_human Elevation of SSAO activity is observed in atherosclerosis, diabetes mellitus and obesity. 23154672 2012
Entrez Id: 8639
Gene Symbol: AOC3
AOC3
0.390 Biomarker group BEFREE The effect of interaction between SSAO and ACE in DM complication is of interest. 18413170 2009
Entrez Id: 8639
Gene Symbol: AOC3
AOC3
0.390 AlteredExpression group BEFREE It is possible that the increased SSAO activity in diabetes may be a result of up-regulation due to increase of SSAO substrates, such as methylamine or aminoacetone. 16487546 2006
Entrez Id: 8639
Gene Symbol: AOC3
AOC3
0.390 Biomarker group BEFREE Plasma SSAO correlated positively with duration of diabetes, HbA(1)c and plasma renin, and negatively with plasma angiotensinogen and body mass index. 15830186 2005
Entrez Id: 8639
Gene Symbol: AOC3
AOC3
0.390 AlteredExpression group BEFREE The increased SSAO activity in diabetes is most likely dependent on post-transcriptional modifications or activation of existing inactive enzyme molecules. 15541390 2004
Entrez Id: 8639
Gene Symbol: AOC3
AOC3
0.390 Biomarker group BEFREE No wild-type animals displayed this phenotype.In conclusion, we suggest that this transgenic mouse model may be of great value for increasing the knowledge about to what extent human SSAO contributes to vascular complications in diabetes, and also to which extent inhibition of SSAO can prevent the development of such complications. 12686114 2003