Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 17
Gene Symbol: AAVS1
AAVS1
0.010 Biomarker disease BEFREE This study suggests a potential therapeutic role for AAT in preventing type I diabetes as well as the ability of AAV gene therapy-based approaches to ameliorate disease effectively. 14712302 2004
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.010 AlteredExpression disease BEFREE The reduction in ABCA-1 content was associated with enhanced expression of stearoyl CoA desaturase 1 and decreased expression of janus kinase 2, which were induced by albumin from patients with type 1 diabetes mellitus. 23015358 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.010 AlteredExpression disease BEFREE At the level of mRNA, we found significantly increased expression of MDR1 in the GDM-I group compared to both the T1DM-I (p<0.01) and control groups (p<0.05). 22558111 2012
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.010 Biomarker disease BEFREE The PICRUSt analysis found an increment of genes related to lipid and amino acid metabolism, ABC transport, lipopolysaccharide biosynthesis, arachidonic acid metabolism, antigen processing and presentation, and chemokine signaling pathways in type 1 diabetes. 30224347 2018
Entrez Id: 85320
Gene Symbol: ABCC11
ABCC11
0.010 AlteredExpression disease BEFREE Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin. 15277376 2004
Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
0.010 AlteredExpression disease BEFREE To determine if clinically important drug efflux transporter expression is altered in pregnancies complicated by gestational diabetes mellitus (GDM-I) or type 1 diabetes mellitus (T1DM-I), we compared the expression of multidrug resistance protein 1 (MDR1), multidrug resistance-associated protein 2 (MRP2) and the breast cancer resistance protein (BCRP) via western blotting and quantitative real-time polymerase chain reaction in samples obtained from insulin-managed diabetic pregnancies to healthy term-matched controls. 22558111 2012
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.330 AlteredExpression disease BEFREE Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin. 15277376 2004
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.330 GeneticVariation disease BEFREE Mutations in the ABCC8 gene can cause autoantibody-negative insulin-dependent diabetes. 19342262 2009
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.330 Biomarker disease CTD_human Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes. 18025464 2007
Entrez Id: 6833
Gene Symbol: ABCC8
ABCC8
0.330 GeneticVariation disease BEFREE The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes. 17535866 2007
Entrez Id: 23
Gene Symbol: ABCF1
ABCF1
0.100 GeneticVariation disease GWASDB A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. 17632545 2007
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.010 AlteredExpression disease BEFREE To determine if clinically important drug efflux transporter expression is altered in pregnancies complicated by gestational diabetes mellitus (GDM-I) or type 1 diabetes mellitus (T1DM-I), we compared the expression of multidrug resistance protein 1 (MDR1), multidrug resistance-associated protein 2 (MRP2) and the breast cancer resistance protein (BCRP) via western blotting and quantitative real-time polymerase chain reaction in samples obtained from insulin-managed diabetic pregnancies to healthy term-matched controls. 22558111 2012
Entrez Id: 7920
Gene Symbol: ABHD16A
ABHD16A
0.100 GeneticVariation disease GWASDB A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. 17632545 2007
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.010 Biomarker disease BEFREE Our data support a model wherein ER-stressed β cells contribute to their own demise during T1D pathogenesis and implicate the ABL-IRE1α axis as a drug target for the treatment of an autoimmune disease. 28380378 2017
Entrez Id: 28
Gene Symbol: ABO
ABO
0.140 GeneticVariation disease BEFREE Recently, genetic variants in the ABO blood group have been related to E-selectin levels in a small cohort of patients with type 1 diabetes. 23300549 2012
Entrez Id: 28
Gene Symbol: ABO
ABO
0.140 GeneticVariation disease BEFREE The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined. 27859559 2017
Entrez Id: 28
Gene Symbol: ABO
ABO
0.140 GeneticVariation disease GWASCAT Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. 21829393 2011
Entrez Id: 28
Gene Symbol: ABO
ABO
0.140 Biomarker disease BEFREE We propose that certain HLA alleles contribute to the development of both type 1 diabetes and ABO blood group incompatibility. 12021139 2002
Entrez Id: 28
Gene Symbol: ABO
ABO
0.140 Biomarker disease BEFREE The acetylator phenotype and ABO blood groups were evaluated in 55 normal subjects and in 156 diabetic patients [61 with Type 1 (insulin-dependent) diabetes and 95 with Type 2 (non-insulin-dependent) diabetes]. 6489656 1984
Entrez Id: 27034
Gene Symbol: ACAD8
ACAD8
0.030 GeneticVariation disease BEFREE Known-group validity (type 1 diabetes vs. IBD, higher vs. lower education level) was checked by Mann-Whitney-U-tests. 29266283 2018
Entrez Id: 27034
Gene Symbol: ACAD8
ACAD8
0.030 GeneticVariation disease BEFREE Among individuals with SLE-affected first-degree relatives, the risk was significantly increased for RA (HR = 1.64; 95% CI: 1.35, 1.99; n = 103), IBD (HR = 1.21; 95% CI: 1.02, 1.43; n = 130) and type 1 diabetes mellitus (HR = 1.23; 95% CI: 1.01, 1.48; n = 106). 28339674 2017
Entrez Id: 27034
Gene Symbol: ACAD8
ACAD8
0.030 GeneticVariation disease BEFREE The RR (95% CI) in individuals with a first-degree relative with RA was 2.91 (2.49, 3.42) for SLE; 2.92 (1.62, 5.25) for SSc; 3.13 (2.50, 3.93) for primary SS; 0.95 (0.36, 2.51) for idiopathic inflammatory myositis; 1.96 (1.54, 2.48) for type 1 diabetes mellitus; 3.32 (1.82, 5.95) for multiple sclerosis; 1.31 (1.31, 2.43) for IBD; 2.76 (2.46, 3.10) for AS; and 1.65 (1.54, 1.77) for psoriasis. 28160009 2017
Entrez Id: 176
Gene Symbol: ACAN
ACAN
0.100 Biomarker disease BEFREE These data demonstrate that DM may contribute to IDD by increasing aggrecan degradation and promoting cell apoptosis, which may represent early indicators of the involvement of DM in the pathogenesis of IDD. 30973512 2019
Entrez Id: 176
Gene Symbol: ACAN
ACAN
0.100 Biomarker disease BEFREE Aggrecan and collagen II, which are the main components of the extracellular matrix (ECM) and traditional degenerative markers for IDD, were detected following the treatment with CILP small interfering (si)RNA or recombinant human CILP (rhCILP) at various concentrations to determine whether CILP contributes to IDD by negatively regulating expression of the ECM. 29436660 2018
Entrez Id: 176
Gene Symbol: ACAN
ACAN
0.100 GeneticVariation disease BEFREE Overall, we observed an underlying additive and multiplicative interaction between the aggrecan gene VNTR polymorphism and smoking in symptomatic IDD. 20367118 2010