Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 260431
Gene Symbol: COPD
COPD
0.010 GeneticVariation disease BEFREE These patients were noted to be younger (59 versus 61 years, p < 0.001) and less likely to have insulin-dependent diabetes (3.0 versus 4.4%, p < 0.001), preoperative dyspnea (2.2 versus 6.0%, p < 0.001), COPD (3.0 versus 4.2%, p = 0.011), and hypertension (40.7 versus 46.9%, p < 0.001) than patients who stayed longer. 31686161 2020
Entrez Id: 608
Gene Symbol: TNFRSF17
TNFRSF17
0.010 Biomarker disease BEFREE Some of the claimed negative health outcomes associated with milk consumption, such as cardiovascular diseases and type 1 diabetes may be attributed to an opioid peptide, beta-casomorphin-7 (BCM-7), derived from A1 beta-casein. 31154909 2020
Entrez Id: 100126334
Gene Symbol: MIR885
MIR885
0.010 AlteredExpression disease BEFREE MiR-885-3p is down-regulated and the levels of pro-inflammatory cytokines are increased in peripheral blood mononuclear cells (PBMCs) from T1D patients compared to healthy controls. 31763742 2020
Entrez Id: 3814
Gene Symbol: KISS1
KISS1
0.010 AlteredExpression disease BEFREE In case of DM, levels of KISS1 expression depended on the presence of PE and were higher compared with DM no PE and control groups: (30.6%) in T1DM + PE and (30.1%) in T2DM + PE group. 31811415 2020
Entrez Id: 574413
Gene Symbol: MIR409
MIR409
0.010 Biomarker disease BEFREE We propose that miR-409-3p may represent a new circulating biomarker of islet inflammation and type 1 diabetes severity. 31659408 2020
Entrez Id: 2896
Gene Symbol: GRN
GRN
0.010 Biomarker disease BEFREE Progranulin promotes diabetic fracture healing in mice with type 1 diabetes. 31423598 2020
Entrez Id: 65264
Gene Symbol: UBE2Z
UBE2Z
0.010 Biomarker disease BEFREE Cannabis Use Is Associated With Increased Risk for Diabetic Ketoacidosis in Adults With Type 1 Diabetes: Findings From the T1D Exchange Clinic Registry. 31628116 2020
Entrez Id: 25859
Gene Symbol: PART1
PART1
0.010 Biomarker disease BEFREE Using data from Part 1, Part 2 of the study included the identification of a theory to guide the design of a website, the development of the website, and an 8-week pilot study of the website with parents with a child with T1D. 30592228 2020
Entrez Id: 2829
Gene Symbol: XCR1
XCR1
0.010 Biomarker disease BEFREE In contrast, huAIRE expression in peripheral antigen-presenting cells (APCs) rendered the mice resistance to T1D, while maintaining other tissue-specific autoimmune response and Ab production against an exogenous protein Ag, due to the loss of Xcr1+ DCs, an essential component for activating diabetogenic T-cells in the periphery. 31586207 2020
Entrez Id: 8039
Gene Symbol: PROA
PROA
0.010 Biomarker disease BEFREE A literature review of PRO implementation in these settings, conceptual issues, value and approach, legal and ethical concerns, as well as a case example of PROA in type 1 diabetes are presented. 31710671 2020
Entrez Id: 7498
Gene Symbol: XDH
XDH
0.010 AlteredExpression disease BEFREE The results of this study showed for the first time that XOR activity is associated with glycemic control in patients with T1DM and that XOR activity is associated with vascular endothelial dysfunction. 31093763 2020
Entrez Id: 6778
Gene Symbol: STAT6
STAT6
0.010 Biomarker disease BEFREE Selective loss of STAT6 may contribute to beta cell demise during the progression of type 1 diabetes. 30338340 2019
Entrez Id: 256933
Gene Symbol: NPB
NPB
0.010 Biomarker disease BEFREE Measurements of NPB and NPW, besides leptin and adiponectin, are worth considering in the detailed prognosis of nutritional status in T1DM, primarily in the T1DM pen-treated population. 31110527 2019
Entrez Id: 55885
Gene Symbol: LMO3
LMO3
0.010 Biomarker disease BEFREE It is shown here that in vivo administration of rBTNL2-Ig ameliorates T1D in non-obese diabetic (NOD) mice. 30884196 2019
Entrez Id: 158506
Gene Symbol: CBLL2
CBLL2
0.010 Biomarker disease BEFREE More than a decade after the discovery of a novel type 1 diabetes risk locus on chromosome 16p13, there remains complexity and controversy over the specific gene(s) that regulate diabetes pathogenesis.A new study by Nieves-Bonilla et al. shows that one of these genes, DEXI, is unlikely to contribute to type 1 diabetes pathogenesis and positions the endolysosomal E3 ubiquitin ligase CLEC16A as the primary culprit by which this gene locus influences diabetes risk. 31570815 2019
Entrez Id: 116842
Gene Symbol: LEAP2
LEAP2
0.010 Biomarker disease BEFREE To test this hypothesis, we determined changes in plasma LEAP2 and acyl-ghrelin due to fasting, eating, obesity, Roux-en-Y gastric bypass (RYGB), vertical sleeve gastrectomy (VSG), oral glucose administration, and type 1 diabetes mellitus (T1DM) using humans and/or mice. 31424424 2019
Entrez Id: 6271
Gene Symbol: S100A1
S100A1
0.010 Biomarker disease BEFREE Whether these can be used in diabetes prevention needs to be carefully evaluated in animal models before use in future clinical assays.-Calviño-Sampedro, C., Gomez-Tourino, I., Cordero, O. J., Reche, P. A., Gómez-Perosanz, M., Sánchez-Trincado, J. L., Rodríguez, M. Á., Sueiro, A. M., Viñuela, J. E., Calviño, R. V. Naturally presented HLA class I-restricted epitopes from the neurotrophic factor S100-β are targets of the autoimmune response in type 1 diabetes. 30817223 2019
Entrez Id: 9938
Gene Symbol: ARHGAP25
ARHGAP25
0.010 Biomarker disease BEFREE SCAF11, CISH and ARHGAP25 were identified to possess value as potential diagnostic markers for children with T1D. 30942443 2019
Entrez Id: 59352
Gene Symbol: LGR6
LGR6
0.010 AlteredExpression disease BEFREE Interestingly, exogenous streptozotocin injection to induce T1D led to marked decreases in ovary size, expression of luteinizing hormone/chorionic gonadotropin receptor in the ovaries, the number of corpora lutea per ovary, oocyte maturation, and serum progesterone levels. 31250581 2019
Entrez Id: 619554
Gene Symbol: MIR486-1
MIR486-1
0.010 Biomarker disease BEFREE miR-486-5p can inhibit inflammatory response, ECM degradation and apoptosis in NP cells by directly targeting FOXO1, which may contribute to the biological therapy of IDD. 30790508 2019
Entrez Id: 2108
Gene Symbol: ETFA
ETFA
0.010 Biomarker disease BEFREE Abbreviations: AGA: anti-gliadin antibodies; Anti-DGP-ab: anti-deamidated gliadin peptide antibodies; Anti-tTG-ab: anti-tissue transglutaminase antibodies; ATD: auto-immune thyroid disorders; BMD: bone mineral density; CD: coeliac disease; DH: dermatitis herpetiformis; EMA: anti-endomysial antibodies; FDR: first-degree relatives; GFD: gluten-free diet; HbA1c: haemoglobin A1c; HLA: human leucocyte antigen; IBS: irritable bowel syndrome; LMIC: low- and middle-income countries; NPV: negative predictive value; NRCD: non-responsive coeliac disease; POCT: point-of-care tests; SDR: second-degree relatives; SIBO: small intestinal bacterial overgrowth; T1DM: type 1 diabetes mellitus; ULN: upper limit of normal. 30099930 2019
Entrez Id: 5199
Gene Symbol: CFP
CFP
0.010 Biomarker disease BEFREE The present study investigated the effects of fat-protein (CFP) counting in addition to carbohydrate (CARB) counting for calculating prandial insulin dosage on blood glucose profile in patients with type 1 diabetes (T1D) on basal-bolus insulin therapy. 31647139 2019
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
0.010 Biomarker disease BEFREE These results suggest that aerobic exercise training affects hepatic asprosin-dependent PKA/TGF-β and AMPK downstream pathways in T1DM. 31083617 2019
Entrez Id: 2169
Gene Symbol: FABP2
FABP2
0.010 Biomarker disease BEFREE Also indicative of diabetic gut barrier dysfunction, increased levels of peptidoglycan and FABP-2 (intestinal fatty acid-binding protein 2) were observed in plasma of human subjects with type 1 diabetes mellitus (n=21) and type 2 diabetes mellitus (n=23) compared with nondiabetic controls (n=23). 31610731 2019
Entrez Id: 9423
Gene Symbol: NTN1
NTN1
0.010 AlteredExpression disease BEFREE Methods Netrin-1 levels in spot urine samples from 82 children with T1D (median age 13.6 years) without MA or hypertension and from 59 healthy controls (median age 11.3 years) with a similar distribution of age and body mass index (BMI) were compared. 31219796 2019