| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | Biomarker | disease | BEFREE | Insulin, glutamate decarboxylase (GAD) and the protein tyrosine phosphatase-like molecule IA-2 are major targets of humoral autoimmunity in insulin-dependent diabetes mellitus (IDDM). | 8897011 | 1996 | ||||
|
0.100 | Biomarker | disease | BEFREE | We previously evaluated radioassays for insulin autoantibodies (IAA), glutamate decarboxylase autoantibodies (GAA) and ICA512bdc autoantibodies (ICA512bdcAA) in the prediction of type I diabetes. | 8816974 | 1996 | ||||
|
0.100 | Biomarker | disease | BEFREE | Immunoglobulin variable gene analysis of human autoantibodies reveals antigen-driven immune response to glutamate decarboxylase in type 1 diabetes mellitus. | 7614998 | 1995 | ||||
|
0.100 | Biomarker | disease | BEFREE | Sera from patients with insulin-dependent diabetes immunoprecipitate 64,000-M(r) proteins, distinct from glutamate decarboxylase, that are cleaved to 37,000- and 40,000-M(r) fragments by trypsin. | 7657822 | 1995 | ||||
|
0.100 | Biomarker | disease | BEFREE | Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes. | 8423231 | 1993 | ||||
|
0.100 | Biomarker | disease | BEFREE | Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression. | 8486775 | 1993 | ||||
|
0.100 | Biomarker | disease | BEFREE | The gamma-aminobutyrate-synthesizing enzyme glutamate decarboxylase (GAD; L-glutamate 1-carboxy-lyase, EC 4.1.1.15) is a major target of autoantibodies associated with both early and late stages of pancreatic beta-cell destruction and development of type 1 diabetes. | 7681990 | 1993 | ||||
|
0.100 | Biomarker | disease | BEFREE | Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. | 1370298 | 1992 |