|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Along with demographic factors and HLA-DR-DQ, genotypes for HLA-DPB1 and 5 non-HLA loci conferring risk of both T1D and CD were analyzed.
|
29018046 |
2017 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
To illustrate this methodology, we apply it to a T1D study with eight HLA genes (HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DQA1, HLA-DQB1, HLA-DPA1, and HLA-DPB1) to build a predictive model.
|
27080919 |
2016 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
In T1D non-Hispanic whites, HLA-DRB1*0101 is significantly (P<0.0001) less frequent in TPO-positive than in TPO-negative individuals, whereas HLA-DRB1*0404, -DQB1*0301, and -DPB1*0201 are significantly (P<0.0001) more frequent.
|
26405068 |
2015 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of T1D-associated alleles at other HLA loci (HLA-A, HLA-B, and HLA-DPB1) on DRB1*03:01 haplotypes suggests that DRB3*02:02 on the DRB1*03:01 haplotype can contribute to T1D risk.
|
23462545 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our result confidently establishes that HLA-DP allelic, and its haplotypic, diversity contributes significantly to the risk for T1DM.
|
23121162 |
2013 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To assess the frequency of HLA class II (DPA1, DPB1, DQA1, DQB1 and DRB1) associated to susceptibility or protection toT1DM in a Bengali population of India with diabetes.
|
23441825 |
2013 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
To determine the HLA-DRB1, DQB1, DPB1, A, C, and B genotypes among Japanese children with autoimmune type 1 diabetes.
|
22128760 |
2012 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
HLA DP allelic and haplotypic diversity contributes significantly to the risk for type 1 diabetes; DPB1*0301 (DPA1*0103-DPB1*0301) is associated with susceptibility and DPB1*0402 (DPA1*0103-DPB1*0402) and DPA1*0103-DPB1*0101 with protection.
|
20424227 |
2010 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Taking both studies together, there is evidence for four T1D-associated regions at 30.0 Mb (HLA-A), 31.4 Mb (HLA-B), 32.5 Mb (rs9268831/HLA-DRA) and 33.2 Mb (rs439121/HLA-DPB1) that are independent of HLA-DRB1/HLA-DQB1.
|
19143813 |
2009 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Although the overall distributions did not differ significantly, allele frequency differences were discovered between the controls from Lazio and controls from northern Italy for some alleles previously determined to affect T1D risk, such as A*3002, DPB1*0301, and DPB1*0402.
|
18486765 |
2008 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
[Alleles of HLA-DQB1 and familial aggregation of type 1 diabetes].
|
12878786 |
2004 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the observed DPB1 associations, especially that of the DPB1*0301 allele, with type 1 diabetes are likely to be true associations.
|
15277401 |
2004 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
After taking into account linkage disequilibrium (LD) with DQB1, DQA1 and DRB1 alleles, we found evidence that some DPB1 alleles are associated with modulating the risk of developing T1D.
|
12753653 |
2003 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data showing a high frequency of the DPB1*0401 allele even in the presence of the predisposing DQB1*02 allele in healthy subjects may indicate a protective effect of this combination of HLA alleles against type 1 diabetes.
|
12648278 |
2003 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the role of DPB1-encoded amino acids in the genetic predisposition to type I diabetes mellitus.
|
11975985 |
2002 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The maximum genetic susceptibility to type 1 diabetes (T1DM) in Basques is conferred by extended HLA haplotype F1C30-DR3-DQ2-DPB1*0202.
|
12021133 |
2002 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The observed distribution of HLA class II alleles among Filipino patients and controls strongly supports the notion that specific combinations of alleles at the DRB1, DQB1, DQA1, and DPB1 loci are critical in determining the risk for type 1 diabetes.
|
12445315 |
2002 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the data in Cameroonian diabetes patients suggest the existence of HLA class II predisposing and specific protective markers, but do not support previous reports of a primary association between HLA-DP polymorphism and development of type I diabetes.
|
11532022 |
2001 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
We suggest that the HLA-DP molecule itself contributes to IDDM1.
|
11334427 |
2001 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Addition of DPB1 in a genetic model of IDDM gives a better fit to the data than consideration of DR-DQ alone.
|
11668578 |
2001 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that in addition to alleles at the DRB1, DQA1, DQB1 loci, polymorphism at DPB1 locus also influences the risk of Type I diabetes.
|
10660221 |
2000 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
Analysis of these pools suggests that DPB1 primarily affects susceptibility to, rather than protection from, type 1 diabetes in a dominant fashion.
|
10615959 |
2000 |
|
HLA-DPB1
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, we report type 1 diabetes age-of-onset association with HLA class II (DRB1, DQB1, and DPB1) and class I (A) genes in 222 multiplex families from the Human Biological Data Interchange.
|
10426387 |
1999 |
|
HLA-DPB1
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thirty-four insulin-dependent diabetes mellitus (IDDM) patients from North India were studied with respect to their HLA class II alleles including those of the DRB1, DQA1, DQB1 and DPB1 loci, using the polymerase chain reaction (PCR) and hybridization with sequence-specific oligonucleotide probes (SSOP).
|
10408802 |
1999 |