|
LINC01193
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The CTLA-4 CT60 GG risk genotypes were only associated with T1DM (OR = 1.445, 95% CI 1.1-1.898, P = 0.008).
|
25185645 |
2015 |
|
LINC01193
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The CTLA-4 +49A/G and CT60 polymorphism was associated with T1DM complicated with thyroid autoimmunity (OR = 2·33 and 2·54).
|
21470281 |
2011 |
|
LINC01193
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Previously reported T1D association from both the +49G>A and the CT60 SNPs was replicated.
|
19956097 |
2009 |
|
LINC01193
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Homogeneous groups of 70 patients with AITD, 70 with type 1 diabetes (T1D), 70 with both AITD and T1D (PGA), and 100 healthy controls were genotyped for the CTLA-4 CT60 and TNF-alpha-863 polymorphisms by minisequencing on an ABI PRISM-3100 genetic analyzer.
|
19530270 |
2009 |
|
LINC01193
|
0.090 |
Biomarker
|
disease |
BEFREE |
These results suggest that CTLA4 CT60 affects the genetic susceptibility to fulminant type 1 diabetes.
|
18443194 |
2008 |
|
LINC01193
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, evidence of a statistical interaction with the known T1D susceptibility-associated CTLA4 polymorphism rs3087243 (laboratory name CT60, G>A) was reported (P<0.0001), such that the CBLB SNP rs3772534 G allele was overtransmitted to offspring with the CTLA4 rs3087243 G/G genotype.
|
17209142 |
2007 |
|
LINC01193
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We assessed the association of five SNPs present in the CTLA-4 gene [-318C/T, -1661A/G and -1722C/T in the promoter region, +49A/G in exon 1 and CT60 in the 3' untranslated region (UTR) region] with type 1 diabetes in North Indian subjects.
|
16671945 |
2006 |
|
LINC01193
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the Japanese.
|
17130562 |
2006 |
|
LINC01193
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Autoimmune diseases such as Graves' disease and type 1 diabetes have been linked with +49A/G and CT60 single nucleotide polymorphisms (SNPs) in the 3' UTR of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene.
|
16313305 |
2005 |