Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE The frequencies of the minor subsets of CD25+FOXP3low memory Tregs as well as CD25lowCD127lowFOXP3+ Tregs were also increased in children with T1D. 30723474 2019
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies. 31808541 2019
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE The established T1D SNPs rs1159465 (near IL2RA) and rs75352297 (near CCR2 and CCR3) were positively associated with IL-2Rα and CCL4, respectively (P < .01). 29266506 2018
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease CTD_human Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. 30224649 2018
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE However, stratification by IL2RA single-nucleotide polymorphisms revealed that T1D subjects with the rs3118470 CC risk variant have Tregs with IL-2 signaling defects and an increased proportion of FOXP3<sup>+</sup>IL-17<sup>+</sup> cells before diagnosis. 28053319 2017
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE Notably, we confirmed biologically relevant interaction between IL2RA and FOXP1, linked to the IL-2 signaling pathway and to type 1 diabetes. 27870152 2016
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE This study suggests a possible association between the T allele of PTPN22 gene and TT genotype of IL2RA with T1D in studied Egyptian children, especially, females with early onset diabetes who carried the 1858T allele. 27288719 2016
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE The resulting 31-gene panel was validated with the NanoString nCounter platform and then measured in sorted CD4(+)CD25(hi)CD127(lo) Tregs from children with T1D and age-matched control subjects. 26786322 2016
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 AlteredExpression disease BEFREE A similar reduction of CD25 expression was also found in T1D relatives, more significant in those with positive autoantibodies. 27560779 2016
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE The CTLA4 and IL2RA loci were more strongly associated with double autoimmunity than with either T1D or CeD alone. 26405070 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE Finally, the association between IL2RA and T1D was stronger among IAA-positive than among IAA-negative patients (comparison P=0.028). 26513234 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE Our meta-analysis suggests that all five SNPs in the IL2RA gene are risk factors for T1D risk, and rs11594656, rs2104286 and rs41295061 are the most associated SNPs in the populations investigated. 26249556 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease GWASCAT Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. 25751624 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE A gene-gene interaction in the T1D data were observed between the IL2RA rs2104286 and GIMAP4 rs9640279 (OR 1.52, p = 0.0064) and indicated between INS rs689 and GIMAP5 rs2286899. 25964488 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE We then applied it to fine map the established multiple sclerosis (MS) and type 1 diabetes (T1D) associations in the IL-2RA (CD25) gene region. 26106896 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE Genetic polymorphisms (HLA haplotypes; rs231806, rs231775, and rs3087243 in CTLA4; rs763361 in CD226; and rs706778 in CD25) and T1D-associated autoantibodies were analyzed. 25980680 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE The IL2RA and IL7RA variants had univariate association in MS and T1D, whereas the MGAT1 and CTLA-4 variants associated with only MS or T1D, respectively. 24572742 2014
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE Autoantibodies to insulin (IAA), GAD (GADA), insulinoma-associated antigen-2 (IA-2A) and zinc transporter 8 (ZnT8A) were measured in follow-up sera, and genotyping for type 1 diabetes susceptibility genes (HLA-DR/HLA-DQ, INS variable number of tandem repeats [VNTR] and single nucleotide polymorphisms at PTPN22, PTPN2, ERBB3, IL2, SH2B3, CTLA4, IFIH1, KIAA0350 [also known as CLEC16A], CD25, IL18RAP, IL10, COBL) was performed on the DNA samples of children born to a parent with type 1 diabetes and prospectively followed from birth for up to 22 years. 23539116 2013
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE Three variants were found to be significantly associated with type 1 diabetes (T1D): NLRP1 rs12150220 (OR = 0.71, 95% CI = 0.55-0.92, P = 0.01), IL2RA rs11594656 (OR = 0.86, 95% CI = 0.82-0.91, P<0.00001), and CLEC16A rs725613 (OR = 0.71, 95% CI = 0.55-0.92, P = 0.01). 23922971 2013
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE Our findings suggest that the effect of IL2RA risk alleles on T1D may be partially mediated through epigenetic changes. 23874506 2013
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease GWASCAT 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. 22293688 2012
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease BEFREE We addressed this by examining the impact of an IL2RA haplotype associated with type 1 diabetes on Treg fitness and suppressive function. 22461703 2012
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 GeneticVariation disease GWASDB 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data. 22293688 2012
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.500 Biomarker disease BEFREE We tested the high a priori possibility that well-established non-HLA autoimmunity loci were involved in APSII and confirmed five association signals to APSII, namely: (1) two T1D-associated SNPs, in CTLA4 and IL2RA, suggest their involvement in T1D pathogenesis in this cohort; (2) two SNPs in STAT4 and IL15 not previously associated to endocrinopathies, are possibly involved in co-occurrence of organ autoimmunity in APSII, and; (3) one SNP in TNF alpha showed association to APSII irrespective of AD. 22537753 2012