Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Our findings suggest that the implication of IL-6 in T1D pathogenesis might be more complex than previously assumed. 31809899 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Emerging evidence has revealed that increase in the levels of pro-inflammatory cytokines, such as interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α), can activate a variety of signaling pathways, eventually resulting in IDD. 30945295 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Liraglutide treatment reduced interleukin-6 in adults with type 1 diabetes but did not improve established autonomic or polyneuropathy. 31338868 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE In conclusion, this study indicated that aerobic exercise training by a decrease of HbA1c and plasma IL-6, TNF-α and IL-1β could decrease MSTN levels in plasma and skeletal muscle in T1DM. 31054482 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE The levels of the production of Interleukin 1β (IL-1β) and IL-6 were significantly increased in MOs from patients with T1D when compared to MOs from healthy controls (respectively, p < 0.01 and p < 0.05). 31322069 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE In addition, the blood chemistry profile complements the TEM data as demonstrated by an increase in serum levels of alanine aminotransferase (ALT), dyslipidemia, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and malondialdehyde (MDA) by T1DM that were significantly (p < 0.05) reduced with insulin injections. 30497321 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE In patients with T1D, there is some evidence that higher levels of high-sensitivity C-reactive protein (hsCRP), IL-6, IL-1 receptor antagonist (IL-1RA) and sICAM-1 may be related to depressive symptoms or (for hsCRP) lower treatment response. 30778653 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Insulin also significantly inhibited T1DM-induced hyperglycemia (p < 0.001), dyslipidemia (p < 0.0001), malondialdehyde (MDA; p < 0.0001), tumor necrosis factor-alpha (TNF-α; p < 0.001) and interleukin-6 (p < 0.001). 31185481 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Proteins of TNF-α and IL6 Pathways Are Elevated in Serum of Type-1 Diabetes Patients with Microalbuminuria. 29445381 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE This study evaluated the association of four distinct dietary quality indices (Dietary Approaches to Stop Hypertension (DASH), Healthy Eating Index 2010 (HEI2010), modified KIDMED and Total Antioxidant Capacity (TAC)) with biomarkers of inflammation (C-reactive protein (CRP), fibrinogen and interleukin-6 (IL-6)) in a sample of 2520 youth with T1D participating in the SEARCH for Diabetes in Youth Study. 29198994 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 GeneticVariation disease BEFREE Spontaneous IDD in the SPARC-null mice caused a dysregulation of interleukin (IL)-1β, IL6, transforming growth factor-beta (TGFβ1), and adiponectin expression. 30273227 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE In youth with T1D, glucose rate of disappearance correlated with free fatty acid at the 80-mU/m2/min phase (P = 0.005), markers of inflammation (IL-6; P = 0.012), high-sensitivity C-reactive protein (P = 0.001), and leptin (P = 0.008)], but not hemoglobin A1c. 30020457 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE However, faster STAT3 activation after TCR stimulation without concomitant increase in IL-6 expression was observed in T cells from patients with T1D. 30006377 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Type 1 diabetes mellitus (type 1 DM) is due to autoimmune destruction of pancreatic β cells because of enhanced production of IL-6 and tumor necrosis factor-α (TNF-α) and other pro-inflammatory cytokines released by immunocytes infiltrating the pancreas in response to unknown exogenous and endogenous toxin(s). 28824543 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression disease BEFREE Patients with T1DM were found to be linked to elevated level of serum IL-6, which the age, ethnic and disease durations in T1DM patients had no effect on the serum IL-6 levels for promoting diabetes mellitus. 28283222 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Proinflammatory cytokines such as IL-1<i>β</i>, IL-6, TNF-<i>α</i>, IFN-<i>γ</i>, IL-12, IL-17, and NO can be released by CD4 and CD8<sup>+</sup> lymphocytes as well as by classically activated macrophages (CAM<i>ϕ</i>s), which are important in the development of T1D. 29249872 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE In summary, our study demonstrates enhanced T cell responses to IL-6 in T1D due, in part, to an increase in IL-6R surface expression. 27629486 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 GeneticVariation disease BEFREE Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin-to-creatinine ratio. 25384728 2015
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Postprandially, patients with T1D and controls showed significant increases in eight inflammatory cytokines (IL-6, TNF-α, IL-1β, IFN-α, IL-10, IFN-γ, IL-12 and MIP-1β) without concomitant increase in serum LPS activity. 25182144 2015
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 GeneticVariation disease BEFREE In summary, the present meta-analysis suggests that IL-6 gene -174 G/C polymorphism is not associated with T1DM risk. 23246692 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 GeneticVariation disease BEFREE This meta-analysis suggests that the IL-6 -174 polymorphism might not confer susceptibility to RA/T1D. 23601344 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE The Th17 cells induced by IL-23 plus IL-6 (termed as effector Th17, Teff17 cells) are pathogenic upon adoptive transfer into non-obese diabetic (NOD) mice contributing to the development of type 1 diabetes (T1D) while cells induced by TGF-β plus IL-6 (termed as regulatory T cells, Treg17 cells) are non pathogenic and regulatory, and suppressed the pathogenic T cells in T1D. 24434314 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Moreover, a possible role of TNF-alpha and IL-6 SNPs cannot be ruled out, although their association with T1D was due to strong LD with the HLA class II susceptibility allele or did not withstand statistical correction, respectively. 20686866 2010
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 GeneticVariation disease BEFREE The -174GG interleukin-6 genotype is protective from retinopathy and nephropathy in juvenile onset type 1 diabetes mellitus. 19542902 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker disease BEFREE Plasma concentrations of soluble intercellular adhesion molecule 1 (sICAM-1; p < 0.05) and IL-6 (p = 0.08) were higher in the PGDM offspring. 19034420 2009