Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 Biomarker disease BEFREE Our goal was to test the hypothesis that administration of tetrahydrobiopterin (BH<sub>4</sub>) would improve impaired endothelial nitric oxide synthase-dependent dilation of cerebral arterioles during type 1 diabetes. 27941054 2017
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE A total of 244 subjects (age 13.8 ± 2.8 years, 125 males) were studied for NOS3 and/or folate pathway polymorphisms using polymerase chain reaction/restriction fragment length polymorphism, including at baseline: 139 with type 1 diabetes; 58 with obesity; and 47 controls. 25477161 2015
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE Endothelial nitric oxide synthase T(-786)C polymorphism in children and adolescents with type 1 diabetes and impaired endothelium-dependent dilatation. 21912080 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 Biomarker disease CTD_human Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats. 21666113 2011
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE This study aimed to clarify the association of NOS3 variants with nephropathy in individuals with type 1 diabetes. 20962522 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE In this study the influence of a single nucleotide polymorphism at position -786 in the eNOS gene, where there is a C/T base substitution, on development of type 1 diabetes mellitus (T1DM) and its microvascular complications was studied in 249 British Caucasian type 1 diabetics using a case-control association design. 20565248 2010
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 Biomarker disease BEFREE Our conclusion is that the NOS3-gene may be involved in the development of diabetic nephropathy in patients with type 1 diabetes and can be predictive of CVD during follow-up. 19246226 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE In the present study we investigated the association of the eNOS gene intron 4 a/b VNTR polymorphism with diabetic microangiopathy in 61 young individuals with type 1 diabetes (T1D), 35 male and 26 female, aged 5.0-29.1 (mean 15.6) years, and followed up for 3.24-11.4 (mean 7.44) years. 19490210 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE We hypothesized that polymorphisms in the NOS3 gene may be associated with the differences seen in arterial stiffness within the population of children with type 1 diabetes. 17327342 2007
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE We therefore studied association between DN and two polymorphisms in NOS3, Glu298Asp and NOS4ab, in Caucasian type 1 diabetes (T1D) patients. 17101543 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene have been associated with the development of diabetic retinopathy (DR) in patients with type 1 diabetes mellitus (T1DM), but not with T2DM. 16581274 2006
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE Recently, we reported a strong association between the eNOS4b/a endothelial nitric oxide synthase (eNOS) polymorphism and severe DR. To examine whether T-786C and C774T eNOS polymorphisms are involved in severe DR, 254 Caucasians with longstanding C-peptide-negative type 1 diabetes, 128 patients with absent/mild DR (control group), and 126 patients with preproliferative/proliferative DR (study group) were genotyped. 15890549 2005
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.400 GeneticVariation disease BEFREE Polymorphisms in the endothelial nitric oxide synthase gene (eNOS) may be implicated in the development of nephropathy in patients with type 1 or insulin-dependent diabetes mellitus (IDDM). 10652017 2000