Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.430 | Biomarker | disease | CTD_human | Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. | 30224649 | 2018 | ||||
|
0.430 | GeneticVariation | disease | BEFREE | In Subtype 2, a significantly higher incidence was observed in T1D cases carrying the TYK2 promoter variant (OR, 2.60; 95%CI, 1.03-6.97; p=0.032), and also showing a flu-like syndrome at diabetes onset (OR, 2.34; 95%CI, 1.27-4.35; p=0.003). | 28826655 | 2017 | ||||
|
0.430 | GeneticVariation | disease | BEFREE | Polymorphisms in the TYK2 gene predicted to decrease function are associated with a decreased risk of developing type 1 diabetes. | 26239055 | 2015 | ||||
|
0.430 | GeneticVariation | disease | BEFREE | A TYK2 promoter haplotype with multiple genetic polymorphisms, which are in complete linkage disequilibrium, named TYK2 promoter variant, presenting decreased promoter activity, is associated with an increased risk of not only T1D (odds ratio (OR), 2.4; 95% confidence interval (CI), 1.2 to 4.6; P = 0.01), but also T2D (OR, 2.1; 95% CI, 1.1 to 4.1; P = 0.03). | 26288847 | 2015 | ||||
|
0.430 | GeneticVariation | disease | GWASCAT | Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. | 25751624 | 2015 | ||||
|
0.430 | GeneticVariation | disease | GWASCAT | Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. | 21829393 | 2011 | ||||
|
0.430 | GeneticVariation | disease | GWASCAT | The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. | 19966805 | 2010 | ||||
|
0.430 | GeneticVariation | disease | GWASDB | The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. | 19966805 | 2010 |