Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE This study aimed to explore the role of PTPN22 in the homeostasis of B cells and its influence in T1D. 31732921 2020
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies. 31808541 2019
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE The aim of this meta-analysis was to determine the association of common type 1 diabetes (T1D) and type 2 diabetes (T2D) gene variants (protein tyrosine phosphatase non-receptor 22 [PTPN22] rs2476601C/T, insulin [INS] rs689A/T and transcription factor 7-like 2 [TCF7L2] rs7903146C/T) with latent autoimmune diabetes in adults (LADA). 30456822 2019
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE A significant association was detected between the variant genotype of the PTPN22 gene (C1858T, rs2476601) and T1DM in Kuwaiti Arabs. 29924845 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease CTD_human Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. 30224649 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE The -1123G > C SNP in the PTPN22 gene promoter and HLA DRB1*0405-DQB1*0401 might influence the concurrence of systemic and organ-specific ADs in patients with type 1 diabetes. 29762907 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE The PTPN22 +1858 allele and genotype distribution were markedly different between APS, type 1 diabetes [T1D; odds ratio (OR): 2.67; 95% confidence interval (CI): 1.52 to 4.68; P = 0.001], Graves disease (GD; OR: 1.94; 95% CI: 1.16 to 3.25; P = 0.011), and controls (OR: 3.31, 95% CI: 1.82 to 6.02; P < 0.001). 29409002 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Autoimmunity-Associated PTPN22 Polymorphisms in Latent Autoimmune Diabetes of the Adult Differ from Those of Type 1 Diabetes Patients. 29895027 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE The data presented here suggests that the T allele of PTPN-22 C1858T polymorphism might be a risk factor for T1D development in Saudi children. 29611765 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE PTPN22 (that encodes a tyrosine phosphatase) has been associated with the development of several autoimmune diseases, including type 1 diabetes, rheumatoid arthritis and systemic lupus erythematosus. 29512901 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE A C1858T single nucleotide polymorphism within PTPN22 (which encodes PTPN22<sup>R620W</sup>) is associated with an enhanced susceptibility to multiple autoimmune diseases including type 1 diabetes and rheumatoid arthritis. 30139951 2018
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE Expert commentary: Current data suggest that PTPN22 can be a promising target for therapeutic interventions and identification of at-risk subjects in autoimmune diseases such as T1D. 27892782 2017
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Predisposition to T1D conferred by PTPN22 and INS-VNTR and protection against T1D conferred by the DRB1*16 allele were confirmed. 28262800 2017
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Among these, a nucleotide polymorphism of the gene encoding for the protein tyrosine phosphatase non-receptor type 22 (PTPN22) has been associated with T1D in several studies. 26902538 2017
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE The PTPN22 rs2476601 minor allele (A) was associated with T1D in Iran, accounting for its pathophysiology in autoimmune diseases. 28375784 2017
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Our aims were to investigate the distribution of selected PTPN22 and FCRL3 gene polymorphisms and their associations with clinical course of disease in children with newly diagnosed T1DM from the Pomeranian region of Poland. 27615679 2017
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE This is the first report demonstrating enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice. 27207523 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE This study suggests a possible association between the T allele of PTPN22 gene and TT genotype of IL2RA with T1D in studied Egyptian children, especially, females with early onset diabetes who carried the 1858T allele. 27288719 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE These findings demonstrate that in addition to common variants, rare deleterious variants in PTPN22 exist and can affect T1D risk. 26631741 2016
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 Biomarker disease BEFREE This review article is focused on the impact of SNP's in PTPN2 (protein tyrosine phosphatase, non-receptor type 2) and PTPN22 (protein tyrosine phosphatase non-receptor type 22) on the development of Crohn's disease and T1D. 26734582 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE Our results indicate that genetic polymorphisms in the PTPN22 gene may increase the risk of T1DM in Chinese children and adolescents. 25729936 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease GWASCAT Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes. 25936594 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE The human ortholog of Ptpn22, PTPN22, is associated with numerous autoimmune diseases, including T1D. 26438525 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 GeneticVariation disease BEFREE In addition, our results suggest a significant effect on T1D susceptibility for AC (Z score=2.30; p=0.02) and CTGGC (Z score=2.309, p=0.02) haplotypes of ZAP70 and PTPN22 genes, respectively. 25448703 2015
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
0.900 SusceptibilityMutation disease RGD These findings are consistent with a role for rat Ptpn22 allelic variation within Iddm26.2 in the regulation of T cell responses, and subsequently the risk for development of T1D. 25505293 2015