Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 GeneticVariation disease BEFREE The chromosomal localization of apM-1 was investigated by FISH and mapped to human chromosome 1q21.3-1q23, a region that was identified as a susceptibility locus for Familial Combined Hyperlipidaemia (FCH) and polygenic NIDDM. 10403784 1999
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 AlteredExpression disease BEFREE Prospective longitudinal studies revealed that the plasma levels of adiponectin declined at an early phase of obesity and remained decreased after the development of type 2 diabetes. 11334417 2001
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 GeneticVariation disease BEFREE Genome-wide scans have mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome to chromosome 3q27, where the adiponectin gene is located. 11756320 2002
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 GeneticVariation disease BEFREE Although family-based association analysis with T2D did not reach significance, our results suggest that an at-risk haplotype of common variants located in the promoter and rare mutations in exon 3 contribute to the variation of the adipocyte-secreted adiponectin hormone level, and may be part of the genetic determinants for T2D in the French Caucasian population. 12354786 2002
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 Biomarker disease CTD_human Adiponectin and development of type 2 diabetes in the Pima Indian population. 12114044 2002
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 Biomarker disease BEFREE Based on these findings together with the observation that adiponectin improves insulin sensitivity in animal models, we conclude that the adiponectin gene may be a susceptibility gene for type 2 diabetes. 11812766 2002
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 GeneticVariation disease BEFREE Here, we screened Japanese patients with type 2 diabetes and age- and BMI-matched nondiabetic control subjects for mutations in adiponectin gene. 12086969 2002
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 Biomarker disease CTD_human Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. 12354786 2002
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 Biomarker disease BEFREE However, adiponectin plasma concentrations are low in obese subjects, and hypoadiponectinemia is associated with the metabolic syndrome, which is a cluster of insulin resistance, type 2 diabetes mellitus, hypertension, and dyslipidemia. 12788102 2003
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 Biomarker disease BEFREE Linkage was also present after inclusion of adiponectin concentrations of siblings with type 2 diabetes not treated pharmacologically (total siblings 582, 182 families, 860 sib-pairs: LOD = 3.5). 12941784 2003
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 Biomarker disease BEFREE Plasma adiponectin concentration is reduced in obese animals and humans and in patients with type 2 diabetes mellitus. 12601307 2003
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 AlteredExpression disease BEFREE Low levels of adiponectin are associated with low levels of HDL-cholesterol independently from common metabolic risk factors and therefore represent an independent cardiovascular risk factor in type 2 diabetes. 12804757 2003
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 Biomarker disease LHGDN Adiponectin may be the link between adiposity, inflammation, and type 2 diabetes. 12766104 2003
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 GeneticVariation disease BEFREE We conclude that adiponectin is independently associated with a reduced risk of type 2 diabetes in apparently healthy individuals. 12547549 2003
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 AlteredExpression disease BEFREE Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. 12802337 2003
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 AlteredExpression disease BEFREE In Pima Indians, high plasma adiponectin levels are associated with increased insulin sensitivity and reduced risk of type 2 diabetes. 12540592 2003
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 GeneticVariation disease BEFREE Adiponectin gene polymorphisms have recently been reported to be associated with obesity, insulin sensitivity, and the risk of type 2 diabetes. 12750819 2003
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 GeneticVariation disease BEFREE Genetic variation at the adiponectin locus and risk of type 2 diabetes in women. 14693717 2004
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 Biomarker disease BEFREE The complex aetiology of Type 2 diabetes, which probably involves a medley of molecular mechanisms, requires dissection out of diabetes-associated subphenotypes, such as the non-obese with increased liver fat or the obese with low plasma adiponectin. 15114471 2004
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 AlteredExpression disease BEFREE This result indicated that the type 2 diabetes susceptibility locus at 3q27 influences both genetic predisposition to type 2 diabetes and serum adiponectin levels in patients with type 2 diabetes. 15504979 2004
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 Biomarker disease BEFREE We have reported that adiponectin has antiatherogenic and antidiabetic properties, and that the plasma levels negatively correlated with body mass index (BMI) are significantly low in patients with CAD or type 2 diabetes. 15063429 2004
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 Biomarker disease BEFREE Plasma adiponectin concentrations were found lower in diabetes mellitus type 2 patients with coronary artery disease. 15682645 2004
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 AlteredExpression disease BEFREE However, first-degree relatives of subjects with type 2 diabetes and those without a family history of diabetes had normal and comparable levels of CRP, adiponectin, and complement proteins. 15277436 2004
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 GeneticVariation disease BEFREE The present study provides additional evidence that SNPs in the proximal promoter region of the APM1 gene contribute to the development of type 2 diabetes. 14749263 2004
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.600 GeneticVariation disease BEFREE Adiponectin gene polymorphisms (single nucleotide polymorphisms [SNPs]) have been associated with BMI, insulin sensitivity, and type 2 diabetes in some cross-sectional studies. 15047634 2004