Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160 2012
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Maturity-onset diabetes of the young 3 (MODY3) is a type of NIDDM caused by mutations in the transcription factor hepatocyte nuclear factor-1alpha (HNF-1alpha) located on chromosome 12q. 9166684 1997
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE In view of her presentation at such a young age and strong family history, a possibility of maturity onset diabetes in young was considered and the genetic test confirmed hepatocyte nuclear factor-1 α mutation on chromosome 12. 22665711 2012
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE The HNF1A mutation p.Pro409His can be considered a mild variant that confers a moderate risk of type 2 diabetes mellitus in heterozygous carriers. 30963309 2019
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE HNF1 alpha gene coding regions mutations screening, in a Caucasian population clinically characterized as MODY from Argentina. 21168233 2011
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Our results indicate that MODY3 mutations are not rare in Korean early-onset type 2 diabetes patients in Korea and suggest that MODY3 mutations in patients with early-onset type 2 diabetes need to be further evaluated. 19119252 2008
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE This study demonstrated that the common HNF1A diplotype of three risk variants may be an independent risk factor for the development of DR resulting from poor glycemic control in normal-weight patients with T2DM. 27445006 2017
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease LHGDN Low prevalence of MODY2 and MODY3 mutations in Brazilian individuals with clinical MODY phenotype. 18672310 2008
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Successful maintenance on sulphonylurea therapy and low diabetes complication rates in a HNF1A-MODY cohort. 26479152 2016
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Mutations in the hepatic nuclear factor-1 alpha and glucokinase are associated with Type II diabetes in 14 % and 7 % of Italian families, respectively. 11692182 2001
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Novel mutations in GCK and HNF1A genes in Italian families with MODY phenotype. 19150152 2009
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE The data also indicate that the G191D mutation in TCF1 plays little, if any, role in susceptibility to common type 2 diabetes in the Japanese. 9840451 1998
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE The HNF1A G319S carrier status was associated with incident type 2 diabetes (odds ratio [OR] 3.78 [95% CI 2.13-6.69]) after adjustment for age, sex, hypertension, triglyceride, HDL cholesterol, and waist circumference. 21208426 2011
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE A novel mutation in the hepatocyte nuclear factor-1alpha/MODY3 gene in Chinese subjects with early-onset Type 2 diabetes mellitus in Taiwan. 10872540 2000
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE The HNF1A variant p.Ala180Val does not seem to cause MODY3, although it may confer risk for type 2 diabetes mellitus. 28934671 2017
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Mice deficient in hepatocyte nuclear factor 1 alpha (HNF-1alpha) develop dwarfism, liver dysfunction, and type 2 diabetes mellitus. 12529398 2003
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE The impact of the G319S mutation at the population level was assessed by classifying subjects with type 2 diabetes according to HNF1A genotype and plotting the cumulative age of onset of diabetes. 11904371 2002
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease LHGDN Mutations in the hepatocyte nuclear factor-1alpha gene in Chinese MODY families: prevalence and functional analysis. 12107757 2002
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE The G319S HNF1A variant is associated with an increased risk of type 2 diabetes in the Canadian Oji-Cree population. 18586913 2008
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Thirty-two Brazilian families with MODY phenotype were screened for GCK and HNF1A mutations. 25174781 2014
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE The ghrelin levels were higher in HNF1A-MODY and GCK-MODY than in T1DM and T2DM (p < 0.001 for all comparisons) but lower than in non-diabetic controls (1.02 ± 0.29 ng/ml, p < 0.001 for both comparisons). 25987348 2015
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Therefore one family member had classical type 2 diabetes including metabolic syndrome aggravated by a genetic predisposition in the form of HNF1A-MODY. 27142837 2016
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease LHGDN GCK and HNF1A mutations in Canadian families with maturity onset diabetes of the young (MODY). 12442280 2002