Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE In the case-control study, no significant difference in apoM concentration was observed between MODY3 and type 2 diabetes patients, neither before nor after adjustment for total cholesterol. 19754856 2010
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160 2012
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE We infer the existence of a gene NIDDM2 causing NIDDM associated with low insulin secretion, and suggest that NIDDM2 and MODY3 may represent different alleles of the same gene. 8782826 1996
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Maturity-onset diabetes of the young 3 (MODY3) is a type of NIDDM caused by mutations in the transcription factor hepatocyte nuclear factor-1alpha (HNF-1alpha) located on chromosome 12q. 9166684 1997
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE One region, upstream of the gene FAM78B, contains three binding sites for the transcription factor PPARG and two binding sites for HNF1A, both previously implicated in the pathology of type 2 diabetes. 22216000 2011
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE In view of her presentation at such a young age and strong family history, a possibility of maturity onset diabetes in young was considered and the genetic test confirmed hepatocyte nuclear factor-1 α mutation on chromosome 12. 22665711 2012
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE The HNF1A mutation p.Pro409His can be considered a mild variant that confers a moderate risk of type 2 diabetes mellitus in heterozygous carriers. 30963309 2019
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE HNF1 alpha gene coding regions mutations screening, in a Caucasian population clinically characterized as MODY from Argentina. 21168233 2011
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Our results indicate that MODY3 mutations are not rare in Korean early-onset type 2 diabetes patients in Korea and suggest that MODY3 mutations in patients with early-onset type 2 diabetes need to be further evaluated. 19119252 2008
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1alpha], HNF4A, GIP, and GLP1R) are associated with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes in participants of the Finnish Diabetes Prevention Study. 15983230 2005
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE This study demonstrated that the common HNF1A diplotype of three risk variants may be an independent risk factor for the development of DR resulting from poor glycemic control in normal-weight patients with T2DM. 27445006 2017
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease LHGDN Low prevalence of MODY2 and MODY3 mutations in Brazilian individuals with clinical MODY phenotype. 18672310 2008
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Successful maintenance on sulphonylurea therapy and low diabetes complication rates in a HNF1A-MODY cohort. 26479152 2016
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 AlteredExpression disease BEFREE After adjusting for multiple covariates, SNPs in ABCA1, GCKR, BAZ1B, TOMM40, and HNF1A were identified as significantly associated with triglyceride levels in T2D patients (P < 0.05). 26252223 2015
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE Qualitative Parameters of the Colonic Flora in Patients with HNF1A-MODY Are Different from Those Observed in Type 2 Diabetes Mellitus. 27807544 2016
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Mutations in the hepatic nuclear factor-1 alpha and glucokinase are associated with Type II diabetes in 14 % and 7 % of Italian families, respectively. 11692182 2001
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Novel mutations in GCK and HNF1A genes in Italian families with MODY phenotype. 19150152 2009
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE Highly sensitive C-reactive protein (hsCRP) was low in the proband and her father (≤0.1 mg/l) indicating that type 2 diabetes was unlikely, and that hepatocyte nuclear factor 1-α-maturity onset diabetes of the young (HNF1A-MODY) was the most likely diagnosis. 22787179 2012
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE To evaluate insulin sensitivity and insulin secretion in prediabetic and diabetic subjects with mutations in MODY1 (HNF-4 alpha) and MODY3 (HNF-1 alpha) genes, in subjects with GAD antibodies, latent autoimmune diabetes in adults and in subjects with the common form of Type II (non-insulin-dependent) diabetes mellitus. 11151756 2000
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE The data also indicate that the G191D mutation in TCF1 plays little, if any, role in susceptibility to common type 2 diabetes in the Japanese. 9840451 1998
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE HNF1-beta and JAZF1 genes are associated with T2D and prostate cancer. 19558691 2009
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease CTD_human Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE The HNF1A G319S carrier status was associated with incident type 2 diabetes (odds ratio [OR] 3.78 [95% CI 2.13-6.69]) after adjustment for age, sex, hypertension, triglyceride, HDL cholesterol, and waist circumference. 21208426 2011
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE A novel mutation in the hepatocyte nuclear factor-1alpha/MODY3 gene in Chinese subjects with early-onset Type 2 diabetes mellitus in Taiwan. 10872540 2000