Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 CausalMutation disease CLINVAR
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 SusceptibilityMutation disease CLINVAR
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease HPO
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Linkage analyses of the MODY3 locus on chromosome 12q with late-onset NIDDM. 7556965 1995
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE We infer the existence of a gene NIDDM2 causing NIDDM associated with low insulin secretion, and suggest that NIDDM2 and MODY3 may represent different alleles of the same gene. 8782826 1996
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE MODY3 and NIDDM subjects had significantly higher fasting glucose levels than subjects in the other groups. 8875082 1996
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Here we show that subjects with the MODY3-form of NIDDM have mutations in the gene encoding hepatocyte nuclear factor-1alpha (HNF-1alpha, which is encoded by the gene TCF1). 8945470 1996
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE We have examined 10 unrelated Caucasian families in which MODY/NIDDM co-segregated with markers for MODY3 for mutations in the HNF-1alpha gene (TCF1). 9097962 1997
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Thus, genetic variation in the HNF-1 alpha gene is not a common factor contributing to NIDDM susceptibility in white subjects of Danish ancestry. 9112026 1997
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE No evidence for linkage of MODY1 and MODY3 markers to NIDDM in African-American sib pairs was observed. 9133559 1997
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Maturity-onset diabetes of the young 3 (MODY3) is a type of NIDDM caused by mutations in the transcription factor hepatocyte nuclear factor-1alpha (HNF-1alpha) located on chromosome 12q. 9166684 1997
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE MODY is genetically heterogeneous with three different genes identified to date; hepatocyte nuclear factor 4 alpha (HNF-4 alpha) [MODY1], glucokinase [MODY2] and hepatocyte nuclear factor 1 alpha (HNF-1 alpha) [MODY3]. 9243109 1997
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE Mutations in the hepatocyte nuclear factor-1alpha/MODY3 gene in Japanese subjects with early- and late-onset NIDDM. 9287053 1997
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE A missense mutation of R272H (replacement of Arg by His in codon 272) in the DNA binding domain of HNF-1 alpha was found in a subject who developed IDDM 1 year after diagnosis of NIDDM at 8 years of age. 9313763 1997
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE The HNF-1 alpha frameshift mutations were not detected in any late-onset NIDDM subjects, suggesting these mutations do not have a major role in the pathogenesis of NIDDM. 9439666 1997
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE Coronary heart disease was more common in MODY3 than in IDDM (16 vs 4.5%; p < 0.02) but less common than in the older NIDDM patients (33.3%; p < 0.02). 9562352 1998
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease MGD Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. 9566924 1998
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE These results suggest that mutations in the HNF-1 alpha gene are not a major cause of early-onset NIDDM in Japanese. 9621514 1998
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE To evaluate the role of HNF1 alpha in the more common familial type 2 diabetes, we studied 62 families of Northern European origin by linkage analysis and molecular screening. 9626139 1998
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 Biomarker disease BEFREE Our results indicate that the region of chromosome 12q close to MODY3 harbors a novel susceptibility gene or genes for NIDDM. 9792550 1998
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE The data also indicate that the G191D mutation in TCF1 plays little, if any, role in susceptibility to common type 2 diabetes in the Japanese. 9840451 1998
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Furthermore, the regression model indicated that the HNF1A S319 allele affected these traits in a dominant manner in subjects with and without type 2 diabetes. 10634821 2000
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1alpha (TCF1) promoter region in MODY patients. 10649494 2000
Entrez Id: 6927
Gene Symbol: HNF1A
HNF1A
0.900 GeneticVariation disease BEFREE We conclude that in African American individuals under age 50, variation in the HNF1a gene is common but unlikely to be a significant cause of T2DM. 10690959 2000