Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASCAT Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. 30718926 2019
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. 20424228 2010
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE Our results highlight the potential importance of CDKAL1 and HHEX in glucose homeostasis in this Alaska Native population with a low prevalence of T2D, and suggest that these loci should be examined in greater detail in this population. 24112421 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE CONCLUSIONS Polymorphisms in CDKN2A/2B and FTO, but not CDKAL1, may be associated with T2D, and alleles rs8050136 and rs9939609 are likely risk alleles for T2D in this population. 26873362 2016
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE Ultimately, accumulated effects on the glycosylated hemoglobin level by the genetic variation of CDKAL1 might affect susceptibility to type 2 diabetes mellitus. 22290723 2012
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease CTD_human In addition to confirming two recently identified risk variants, we identified a variant in the CDKAL1 gene that was associated with T2D in individuals of European ancestry (allele-specific odds ratio (OR) = 1.20 (95% confidence interval, 1.13-1.27), P = 7.7 x 10(-9)) and individuals from Hong Kong of Han Chinese ancestry (OR = 1.25 (1.11-1.40), P = 0.00018). 17460697 2007
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASDB Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. 22693455 2012
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE The fetal insulin hypothesis proposes that common genetic variants that reduce insulin secretion also reduce birth weight, and an association of low birth weight and the type 2 diabetes risk alleles at the HHEX-IDE and CDKAL1 loci were recently reported. 19622614 2009
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE Taken together, our findings provide evidence for a significant contribution of CDKN2A/B gene rs10811661 and CDKAL1 gene rs7756992 and rs10946398 to type 2 diabetes. 24012816 2013
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1) is a tRNA-modifying enzyme that catalyzes 2-methylthiolation (ms<sup>2</sup>) and has been implicated in the development of type 2 diabetes (T2D). 31189758 2019
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASDB New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. 23575436 2013
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE In addition to confirming two recently identified risk variants, we identified a variant in the CDKAL1 gene that was associated with T2D in individuals of European ancestry (allele-specific odds ratio (OR) = 1.20 (95% confidence interval, 1.13-1.27), P = 7.7 x 10(-9)) and individuals from Hong Kong of Han Chinese ancestry (OR = 1.25 (1.11-1.40), P = 0.00018). 17460697 2007
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE However, no significant association was detected between HHEX (rs1111875), CDKAL1 (rs7756992), or UBE2E2 (rs7612463) and T2D. 29871606 2018
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE Intronic polymorphisms in CDKAL1, a tRNA methylthiotransferase, are associated with increased type 2 diabetes risk. 30247717 2018
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE In addition to TCF7L2, SLC30A8 and HHEX, initially identified by the French GWA scan, CDKAL1, IGFBP2 and CDKN2A/2B strongly associate with T2D in French individuals, and mostly in populations of Central European descent but not in Moroccan subjects. 18461161 2008
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX. 27377502 2016
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASDB Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. 22158537 2011
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE We have identified significant association between variants in CDKN2A/B, CDKAL1 and TCF7L2, and type 2 diabetes in a Han Chinese cohort, indicating these genes as strong candidates conferring susceptibility to type 2 diabetes across different ethnicities. 20161779 2010
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE In the case-control sample, 8 SNPs in or near WFS1, CDKAL1, CDKN2A/2B, CDC123, HHEX, TCF7L2, KCNQ1, and MTNR1B were significantly associated with T2D (P<0.05). 24637646 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE For type 2 diabetes, we detected a recessive effect (p DOMDEV = 5 × 10(-4)) at CDKAL1. 26961502 2016
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASDB A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. 20818381 2010
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASCAT Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility. 27189021 2016
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASCAT Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. 19401414 2009