Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE To gain insight into potential regulatory mechanisms through which the effects of variants at four established type 2 diabetes (T2D) susceptibility loci (CDKAL1, CDKN2A-B, IGF2BP2 and KCNQ1) are mediated, we undertook transancestral fine-mapping in 22 086 cases and 42 539 controls of East Asian, European, South Asian, African American and Mexican American descent. 26911676 2016
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE The transcription factor Sox4 has been proposed to underlie the increased type 2 diabetes risk linked to an intronic single nucleotide polymorphism in CDKAL1 In a mouse model expressing a mutant form of Sox4, glucose-induced insulin secretion is reduced by 40% despite normal intracellular Ca(2+) signaling and depolarization-evoked exocytosis. 26993066 2016
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE We investigated the association between common type 2 susceptibility variants of CDK5 regulatory subunit associated protein 1-like 1(CDKAL1) and therapeutic responses to anti-diabetic agents among patients with type 2 diabetes. 27139004 2016
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE Nonparametric meta-analysis of the Discovery and Translation cohorts identified significant associations at 6p24 (SLC35B3/TFAP2A) with glucose effectiveness/T2D, 11p15 (KCNQ1) with disposition index/T2D, and 6p22 (CDKAL1) and 11q14 (MTNR1B) with acute insulin response/T2D. 25524916 2015
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE We have previously confirmed the associations of genetic variants in HHEX, CDKAL1, VEGFA and FTO with type 2 diabetes in Han Chinese. 25587982 2015
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE There were significant differences between the T2DM and control groups in frequencies of the risk allelic distributions of rs7754840 (CDKAL1) (p=0.014), rs864745 (JAZF1) (p=0.032), and rs35767 (IGF1) (p=0.044). 25785549 2015
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE In this study, we investigated the association of the rs7756992 of CDKAL1 and the rs4402960 of IGF2BP2 with Type 2 diabetes, diabetic complications (nephropathy, retinopathy and cardiovascular disease), obesity and hypertension in a Tunisian population. 24636221 2015
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE Contrary to previous findings, we provide evidence against a role for dysregulated expression of CDKAL1-v1 in mediating the association between intronic SNPs in CDKAL1 and susceptibility to type 2 diabetes. 25634229 2015
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE This study identified the association between type 2 diabetes risk variants in CDKAL1 and birthweight in Chinese Han individuals, and the carrier of risk allele within SRR had the trend of reduced birthweight. 26168825 2015
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE Cyclin- dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1 (CDKAL1) rs10946398, a novel body mass index (BMI)-associated locus specifically in the Asian population, may impair insulin secretion and may be associated with insulin resistance and type 2 diabetes. 26119585 2015
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE We found that inverse associations between habitual coffee intake and the combined risk of type 2 diabetes and prediabetes were limited to those with the T-allele (GT/TT) of rs4402960 in IGF2BP2, those with the G-allele (GG/GC) of rs7754840 in CDKAL1, or those with CC of rs5215 in KCNJ11. 25755232 2015
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE Our results highlight the potential importance of CDKAL1 and HHEX in glucose homeostasis in this Alaska Native population with a low prevalence of T2D, and suggest that these loci should be examined in greater detail in this population. 24112421 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE In the case-control sample, 8 SNPs in or near WFS1, CDKAL1, CDKN2A/2B, CDC123, HHEX, TCF7L2, KCNQ1, and MTNR1B were significantly associated with T2D (P<0.05). 24637646 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASCAT Genome-wide association study identifies three novel loci for type 2 diabetes. 23945395 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE Association analysis of IGF2BP2, KCNJ11, and CDKAL1 polymorphisms with type 2 diabetes mellitus in a Moroccan population: a case-control study and meta-analysis. 24898818 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASCAT T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility. 25483131 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease GWASDB Genome-wide association study identifies three novel loci for type 2 diabetes. 23945395 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE This study reports association of CDKAL1-related SNPs with insulin resistance, a clinical marker related to type 2 diabetes in a cross-sectional cohort of Greek children and adolescents of European descent. 24695378 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE Five risk variants in IGF2BP2 (rs4402960, rs1470579), CDKAL1 (rs10946398), SLC30A8 (rs13266634), and HHEX (rs1111875) genes were nominally associated with T2DM in our samples. 24736664 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE Our results suggest that CDKAL1-v1-mediated suppression of CDKAL1 might underlie the pathogenesis of T2D in individuals carrying the risk SNPs. 24760768 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 Biomarker disease BEFREE The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease. 25483131 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE In addition, simulation analysis indicated that a type 2 diabetes risk variant in CDKAL1 (rs7754840) was selected in East Asians ∼6,900 years ago. 25222615 2014
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
0.700 GeneticVariation disease BEFREE Taken together, our findings provide evidence for a significant contribution of CDKN2A/B gene rs10811661 and CDKAL1 gene rs7756992 and rs10946398 to type 2 diabetes. 24012816 2013