| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.170 | AlteredExpression | disease | BEFREE | Constitutive Activation of β-Catenin in Conventional Dendritic Cells Increases the Insulin Reserve to Ameliorate the Development of Type 2 Diabetes in Mice. | 31048369 | 2019 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | Interestingly one of the genes identified, catenin beta 1 (CTNNB1, β-catenin), is the key effector of the Wnt pathway and interacts with the nuclear receptor transcription factor 7-like 2 (TCF7L2), variants which are the most strongly associated with risk of developing T2D worldwide. | 30212457 | 2018 | ||||
|
0.170 | AlteredExpression | disease | BEFREE | The changes of VCAM-1, eNOS, and the β-catenin expression were also tested in the isolated islets of T2DM rats infused with MSCs. | 28807051 | 2017 | ||||
|
0.170 | Biomarker | disease | BEFREE | Increased fracture risk and elevated Dickkopf-1 levels, which is an inhibitor of Wnt/β-catenin bone metabolic pathway, have been documented in adult patients with type 2 diabetes mellitus (T2D), while no relevant data exist on childhood type 1 diabetes (T1D). | 27766367 | 2017 | ||||
|
0.170 | Biomarker | disease | BEFREE | Association of Canonical Wnt/β-Catenin Pathway and Type 2 Diabetes: Genetic Epidemiological Study in Han Chinese. | 26083111 | 2015 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | Given this observation, we suggest that these loci could possibly modulate shared pathways, in particular with respect to β-catenin, and their respective variants interplay to influence HME pathogenesis as well as T2D. | 25498973 | 2015 | ||||
|
0.170 | GeneticVariation | disease | BEFREE | Our results suggest synergistic effects of WNT16a insertion and the at-risk 'T' allele of TCF7L2 (rs7903146) for elevating the expression of TCF7L2 in human pancreas which may affect the regulation of downstream target genes involved in the development of T2D through Wnt/β-catenin/TCF7L2 signaling pathway. | 23617586 | 2013 | ||||
|
0.170 | Biomarker | disease | HPO |