Gene: CDKAL1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease GWASCAT Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. 30718926 2019
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 Biomarker disease BEFREE CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1) is a tRNA-modifying enzyme that catalyzes 2-methylthiolation (ms<sup>2</sup>) and has been implicated in the development of type 2 diabetes (T2D). 31189758 2019
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease GWASCAT Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. 31118516 2019
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease BEFREE Moreover, the contribution of CDKAL1 polymorphisms to T2D risk seems to be associated with age, gender, BMI, smoking and drinking. 31639799 2019
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease BEFREE However, no significant association was detected between HHEX (rs1111875), CDKAL1 (rs7756992), or UBE2E2 (rs7612463) and T2D. 29871606 2018
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease BEFREE Intronic polymorphisms in CDKAL1, a tRNA methylthiotransferase, are associated with increased type 2 diabetes risk. 30247717 2018
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458 2018
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease GWASCAT Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. 29358691 2018
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease BEFREE Body mass index modulates the association between CDKAL1 rs10946398 variant and type 2 diabetes among Taiwanese women. 30185902 2018
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590 2017
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease BEFREE CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes. 28821857 2017
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease GWASCAT Interaction of iron status with single nucleotide polymorphisms on incidence of type 2 diabetes. 28406950 2017
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 Biomarker disease BEFREE These results suggest that the type 2 diabetes susceptibility gene CDKAL1 has novel functions in regulating mitochondrial activity. 29031721 2017
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 Biomarker disease BEFREE The analysis of the frequency distribution of polymorphic markers for genes <i>KCNJ11, CDKAL1, SLC30A8</i> and <i>CDKN2B</i> showed statistically significant associations with T2DM in the Russian population. 28717589 2017
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease BEFREE Analyzing data from 113 203 non-diabetic UK Biobank participants, we observed three (near TCF7L2, CDKN2AB and CDKAL1) overestimated (body mass index (BMI) decreasing) and one (near MTNR1B) underestimated (BMI increasing) associations among 11 type 2 diabetes risk alleles (at P  <  0.05). 28040731 2017
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 Biomarker disease BEFREE Our results identify CDKAL1 as novel negative regulator of adipocyte differentiation and provide insights into the link between CDKAL1 and metabolic diseases such as type 2 diabetes and obesity. 28779110 2017
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease BEFREE Application of MR-MEGA to fine-mapping four type 2 diabetes susceptibility loci in 22,086 cases and 42,539 controls highlights: (i) strong evidence for heterogeneity in allelic effects that is correlated with ancestry only at the index SNP for the association signal at the CDKAL1 locus; and (ii) 99% credible sets with six or fewer variants for five distinct association signals. 28911207 2017
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease BEFREE A total of 3 SNPs [rs9465871 (CDKAL1), rs10761745 (JMJD1C), and rs163177 (KCNQ1)] were selected as candidate SNPs related to T2D. 28406950 2017
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease BEFREE CONCLUSIONS Polymorphisms in CDKN2A/2B and FTO, but not CDKAL1, may be associated with T2D, and alleles rs8050136 and rs9939609 are likely risk alleles for T2D in this population. 26873362 2016
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 Biomarker disease BEFREE A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX. 27377502 2016
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease BEFREE For type 2 diabetes, we detected a recessive effect (p DOMDEV = 5 × 10(-4)) at CDKAL1. 26961502 2016
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease GWASCAT Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility. 27189021 2016
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease GWASCAT Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. 26818947 2016
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1 		0.700 GeneticVariation disease GWASCAT Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. 26961502 2016