Regression analysis revealed direct associations between the two miRs and albuminuria (P<0.05). miR‑377 was independently associated with DN risk, even following multivariable adjustment, and albuminuria was the only predictor of miR‑377 (P<0.001).
LncRNA TUG1 acts as an endogenous sponge of miR-377 and downregulates miR-377 expression levels, and thereby relieving the inhibition of its target gene PPARγ and alleviates extracellular matrix accumulation of mesangial cells, which provides a novel insight of diabetic nephropathy pathogenesis.
Thus, overexpression of miR-377 in diabetic nephropathy indirectly leads to increased fibronectin protein production; as such, miR-377 can have a critical role in the pathophysiology of this prevalent human disease.