Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5970
Gene Symbol: RELA
RELA
0.350 AlteredExpression disease BEFREE Furthermore, the in vivo study showed that serum and renal cortex AGEs levels, glomerular p65 phosphorylation and heparanase expression were significantly increased in DN mice. 28478303 2018
Entrez Id: 5970
Gene Symbol: RELA
RELA
0.350 Biomarker disease BEFREE In the dual-luciferase reporter assay, TKL significantly inhibited luciferase activity in cells co-transfected with p65 and a wild-type capase-9 construct instead of mutated caspase-9 constructs.Taken together, our results show that TKL helps to protect against DN by inhibiting the LOX1/NF-κB/caspase-9 signaling pathway, suggesting TKL as a promising agent for treating DN. 30038056 2018
Entrez Id: 5970
Gene Symbol: RELA
RELA
0.350 Biomarker disease BEFREE Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory-fibrosis through the NF-κB p65 and Sirt1 pathway; NMN alleviates diabetic nephropathy inflammatory-fibrosis by inhibiting endogenous Nampt. 29104634 2017
Entrez Id: 5970
Gene Symbol: RELA
RELA
0.350 AlteredExpression disease BEFREE Nuclear NF-κB p65 in peripheral blood mononuclear cells correlates with urinary MCP-1, RANTES and the severity of type 2 diabetic nephropathy. 24936866 2014
Entrez Id: 5970
Gene Symbol: RELA
RELA
0.350 Biomarker disease BEFREE Our findings strongly support a critical role for p65 and STAT3 acetylation in DN. 24608443 2014
Entrez Id: 5970
Gene Symbol: RELA
RELA
0.350 Biomarker disease CTD_human Merit of Astragalus polysaccharide in the improvement of early diabetic nephropathy with an effect on mRNA expressions of NF-kappaB and IkappaB in renal cortex of streptozotoxin-induced diabetic rats. 17900838 2007