Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.300 Biomarker group BEFREE Epalrestat is an inhibitor of aldose reductase in the polyol pathway and is used for the management of diabetic neuropathy clinically. 29930278 2019
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.300 Biomarker group BEFREE Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG. 31636082 2019
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.300 Biomarker group BEFREE The increased glucose flux into the polyol pathway via aldose reductase (AR) is recognized as a major contributing factor for the pathogenesis of diabetic neuropathy, whereas little is known about the functional significance of AR in the peripheral nervous system. 29238976 2018
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.300 Biomarker group BEFREE Epalrestat (EPS), an aldose reductase inhibitor, is widely prescribed to manage diabetic neuropathy. 28204799 2018
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.300 Biomarker group BEFREE Epalrestat (EPS) is the only aldose reductase inhibitor that is currently available for the treatment of diabetic neuropathy. 25529839 2015
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.300 Biomarker group RGD Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats. 16900242 2006
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.300 GeneticVariation group BEFREE In this study the association between polymorphisms in the AKR1B1 gene and diabetic neuropathy was investigated. 16176189 2005
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.300 Biomarker group BEFREE Inhibitors of aldose reductase (ARIs) have been widely investigated as potential therapeutic agents, but to date only epalrestat is successfully marketed for treatment of diabetic neuropathy, in Japan. 15095000 2004
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.300 Biomarker group BEFREE These studies clearly demonstrated that AR is crucial to the pathogenesis of these diseases, and that the mechanism leading to diabetic cataract may be different from that which causes diabetic neuropathy. 12871135 2003
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.300 Biomarker group BEFREE The present study was designed to examine the effect of aldose reductase (AR) overexpression on the development of diabetic neuropathy by using mice transgenic for human AR. 11701599 2001
Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
0.300 Biomarker group BEFREE These results suggest that the aldose reductase gene is intimately involved in the pathogenesis of diabetic neuropathy. 9489533 1998