Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 AlteredExpression disease BEFREE The results of this current meta-analysis indicated that the increased level of ICAM-1 generally exists in the patients with DR and it may associated with the severity of DR. 31109934 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Biomarker disease BEFREE The downstream exacerbating factors including vascular endothelial growth factor (VEGF), intercellular adhesion molecule 1 (ICAM-1) and matrix metalloproteinase 2 (MMP2), which are implicated in the pathogenesis of DR and closely related to oxidative stress were also analyzed. 30662833 2019
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE Association between diabetic retinopathy in type 2 diabetes and the ICAM-1 rs5498 polymorphism: a meta-analysis of case-control studies. 30419874 2018
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Biomarker disease BEFREE In conclusion, treatment with Niaspan significantly improved clinical and histopathological outcomes; decreased the expression levels of TNF‑α, NF‑κB, iNOS and ICAM‑1; and decreased apoptosis and BRB breakdown, as compared with in the retinas of DR rats. 28138697 2017
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Biomarker disease BEFREE Intracellular adhesion molecule 1 (ICAM-1) is an important inflammatory factor that causes retinal damage during diabetic retinopathy. 28104396 2017
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 AlteredExpression disease BEFREE Inhibition or knock down of endothelial 12/15-LO in HRECs blocked HG-induced expression of ICAM-1, a well-known identified important molecule for leukocyte adhesion in DR. 28351645 2017
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 AlteredExpression disease BEFREE The data indicated that TUDCA could ameliorate DR by decreasing NO content and down-regulating the protein expression of ICAM-1, NOS, NF-κB p65 and VEGF. 26988565 2016
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE Our results revealed that SNP rs5498 in ICAM-1 gene and IVS5-13insC variant in HMGA1 gene were not associated with the susceptibility of DR in the Chinese T2DM cohort. 26717491 2016
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE Association between the ICAM-1 K469E polymorphism and diabetic retinopathy in Type 2 diabetes mellitus: a meta-analysis. 24612665 2014
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Therapeutic disease RGD Silybin reduces obliterated retinal capillaries in experimental diabetic retinopathy in rats. 25066112 2014
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE Genetic variants in ICAM1, PPARGC1A and MTHFR are potentially associated with different phenotypes of diabetic retinopathy. 25324196 2014
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE A number of studies evaluated the association of intracellular adhesion molecule-1 (ICAM-1) K469E (rs5498, A/G) gene polymorphism with diabetic microvascular complications (DMI) including diabetic nephropathy (DN) and diabetic retinopathy (DR) in different populations. 23922864 2013
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Biomarker disease BEFREE Polymorphisms in NOS3, VEGF, ITGA2, and ICAM1 are also associated with diabetic retinopathy after meta-analysis. 19587357 2009
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Biomarker disease BEFREE Furthermore, ICAM-1 has been demonstrated to be involved in leukocyte-mediated endothelial injury in diabetic retinopathy. 19482023 2009
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE A significantly higher frequency of the EE genotype of the K469E polymorphism of the ICAM-1 was found in the patients with PDR compared with those without diabetic retinopathy (OR = 2.0, 95% confidence interval [CI] = 1.1-3.5; P = 0.013), whereas the G241A polymorphism of the ICAM-1 gene failed to yield an association with PDR. 18942221 2008
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease LHGDN A significantly higher frequency of the EE genotype of the K469E polymorphism of the ICAM-1 was found in the patients with PDR compared with those without diabetic retinopathy (OR = 2.0, 95% confidence interval [CI] = 1.1-3.5; P = 0.013), whereas the G241A polymorphism of the ICAM-1 gene failed to yield an association with PDR. 18942221 2008
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE The ICAM-1 gene K469E polymorphism is associated with diabetic retinopathy in Chinese patients with Type 2 diabetes. 16759306 2006
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Biomarker disease LHGDN Soluble adhesion molecules are not involved in the development of retinopathy in type 2 diabetic patients. 15666579 2004
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease BEFREE The frequency of ICAM-1 469KK genotype and K allele were significantly higher in the patients with diabetic retinopathy than in those without retinopathy (genotype 42% vs. 20%, chi2 = 6.70, P = 0.035; allele 66% vs. 50%, chi2 = 6.49, P = 0.011). 12027924 2002
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 GeneticVariation disease LHGDN The frequency of ICAM-1 469KK genotype and K allele were significantly higher in the patients with diabetic retinopathy than in those without retinopathy (genotype 42% vs. 20%, chi2 = 6.70, P = 0.035; allele 66% vs. 50%, chi2 = 6.49, P = 0.011). 12027924 2002
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.600 Therapeutic disease CTD_human These data identify the causal role of leukocytes in the pathogenesis of diabetic retinopathy and establish the potential utility of ICAM-1 inhibition as a therapeutic strategy for the prevention of diabetic retinopathy. 10485912 1999
Entrez Id: 183
Gene Symbol: AGT
AGT
0.580 GeneticVariation disease BEFREE Binary logistic regression displays that the association of the ACE and AGT gene polymorphisms in DR patients is not significant after adjusting for confounding covariates in all the comparisons. 29378484 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.580 GeneticVariation disease BEFREE 311 T1DM patients were recruited for the assessment of ACE and AGT polymorphisms relating to DR. 29484134 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.580 AlteredExpression disease BEFREE Compared with normal rats, AGT and CD34 were expressed more frequently in DR rats. 29488353 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.580 Biomarker disease BEFREE Potential of angiotensin II receptor blockers in the treatment of diabetic retinopathy. 28363842 2017