Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease BEFREE Oxidant production and SOD1 protein expression in single skeletal myofibers from Down syndrome mice. 28697486 2017
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 Biomarker disease BEFREE We suggest that increased SOD1 expression can lead to tau hyperphosphorylation, which might serve as an important contributing factor to the etiology of Down syndrome and SOD1-related ALS disease. 25524953 2015
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 GeneticVariation disease BEFREE Using cultured fibroblasts with trisomy 21 (T21F), this study aimed to ascertain whether an imbalance exists in activities, mRNA, and protein expression of the antioxidant enzymes SOD1, SOD2, glutathione-peroxidase, and catalase during the cell replication process in vitro. 25852816 2015
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease BEFREE It was hypothesized herein that the presence of CHD may alter the expression of SOD1 and oxidative metabolism in patients with DS. 19593803 2010
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease LHGDN Quantitative evaluation of collagen type VI and SOD gene expression in the nuchal skin of human fetuses with trisomy 21. 17602442 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 GeneticVariation disease BEFREE The missense mutation of SOD1 gene in two of the three alleles could have increased its toxic effects in the Down syndrome patient leading to an earlier onset and rapid progression of the disease. 17624778 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 GeneticVariation disease BEFREE These results highlight DS as a model to understand the role of APOE4 allele in unsuccessful ageing considering that a number of proinflammatory supernumerary genes (Cu/Zn superoxide dismutase, Ets-2 transcription factors, Down syndrome critical region 1, stress-inducible factor, interferon-alpha receptor and the amyloid precursor protein) are located on chromosome 21 and are implied in the pathologic processes of DS. 17559337 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease BEFREE Quantitative evaluation of collagen type VI and SOD gene expression in the nuchal skin of human fetuses with trisomy 21. 17602442 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 GeneticVariation disease LHGDN The missense mutation of SOD1 gene in two of the three alleles could have increased its toxic effects in the Down syndrome patient leading to an earlier onset and rapid progression of the disease. 17624778 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 Biomarker disease BEFREE Our findings suggest that genes on the trisomic Ts1Cje segment other than APP and SOD1 can cause oxidative stress, mitochondrial dysfunction and hyperphosphorylation of tau, all of which may play critical roles in the pathogenesis of mental retardation in DS. 16891409 2006
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease BEFREE A misbalance between SOD-1 and glutathione perioxidase activity in DS has been linked to free radical generation. 17168651 2006
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 Biomarker disease BEFREE Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome. 16716898 2006
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease BEFREE The results demonstrate that the enhancement in the level of mRNAs encoding SOD1 in DS male and female, as well as aged male and female are 51, 21, 31 and 50% respectively compared to the normal child (control). 15670619 2005
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease BEFREE Transgenic mice overexpressing the human copper/zinc superoxide dismutase (SOD1) gene are one of the first murine models for DS and it has been shown that SOD1 overexpression might be either deleterious or beneficial. 15961078 2005
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease BEFREE SOD1 is one of several overexpressed genes in trisomy 21. 15982533 2005
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease BEFREE Down's syndrome (trisomy 21) brain tissue is considered to be susceptible to oxidative injury, mainly because its increased Cu/Zn-superoxide dismutase (SOD1) activity is not followed by an adaptive rise in hydrogen peroxide metabolizing enzymes. 15525277 2004
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 Biomarker disease BEFREE We have therefore investigated global gene expression profiles in Ts1Cje, a mouse model for DS that displays learning deficits and has a segmental trisomy of chromosome 16 orthologous to a segment of human chromosome 21 spanning from Sod1 to Znf295. 15138197 2004
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease BEFREE SOD1 is one of several overexpressed genes in Down's syndrome. 15464862 2004
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 Biomarker disease BEFREE Polysomnography in transgenic hSOD1 mice as Down syndrome model. 15068249 2003
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease BEFREE This suggests that the decreased expression of PRDX2 may contribute to the altered redox state in DS at levels comparable to that of the increased expression of SOD1. 12943237 2003
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease LHGDN No detectable change was found in expression of SOD-1, catalase, phospholipid hydroperoxide glutathione peroxidase, glutathione reductase, antioxidant enzyme AOE372, thioredoxin-like protein and selenium binding protein between control and DS fetuses. 11771762 2001
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 Biomarker disease CTD_human They also show the potentially deleterious effects of SOD1 overexpression on cellular proliferation, which may be relevant to abnormal development in DS. 11181815 2001
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease BEFREE Increased SOD-1 levels in patients with DS may reflect the overexpression by the trisomic state, as a response to the oxidative stress, as has been proposed in DS by several authors. 11217146 2001
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 AlteredExpression disease BEFREE They also show the potentially deleterious effects of SOD1 overexpression on cellular proliferation, which may be relevant to abnormal development in DS. 11181815 2001
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.400 Biomarker disease BEFREE In this regard, beta amyloid precursor protein (APP), CuZn superoxide dismutase (SOD1) and S100beta have been implicated in causing apoptosis, a mechanism thought to be responsible for neuronal loss in DS, in one way or another. 11858695 2001